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Sol-Gel Preparation of HAp-Coated Silica Macrospheres from Water Glass and their Protein Adsorption

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Abstract:

Silica gel macrospheres of 2~4 mm in size, and wrapped with Ca-alginate chelate film were prepared as the substrate for hydroxyapatite coating layer, using water glass as the silica source. Those Ca-SiO2 macrospheres were soaked in a 1:1 (volume) mixture of ethanol and 0.1 M Na2HPO4 to deposit hydroxyapatite layer (HAp-SiO2 macrospheres). Adsorption of bovine serum albumin and egg lysozyme on those Ca-SiO2 and HAp-SiO2 macrospheres under physiological pH (7.2) was well correlated to the Langmuir-type adsorption equation. The electrostatic interactions between the protein molecules and those macrospheres well interpret the adsorption isotherms, while the mesopores in the Ca-SiO2 contributed to some extent. A multi-layer adsorption model was proposed.

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Periodical:

Key Engineering Materials (Volumes 529-530)

Pages:

637-640

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.529-530.637

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Online since:

November 2012

Authors:

Jie Li, Yuki Shirosaki, Satoshi Hayakawa, Artemis Stamboulis, Akiyoshi Osaka

Keywords:

Hydroxyapatite Coating, Protein Adsorption, Silica Gel Macrosphere, Water Glass

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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