Novel Bioactive Materials neither Based on Calcium Phosphate Nor Silicate: Titanium Oxide

Tadashi Kokubo

doi:10.4028/www.scientific.net/KEM.587.141

Paper Titles

Preparation and Characterization of Micro-Nanostructured Anatase Film
p.115

Study of some Dental Biomaterials Properties Using an Original Software Application
p.121

Production and Characterization of Hydroxyapatite/Niobo Phosphate Glass Scaffold
p.128

Influence of Nanograin Size ZrO₂ and Al₂O₃ Ceramics on Biological Response of Cells
p.132

Novel Bioactive Materials neither Based on Calcium Phosphate Nor Silicate: Titanium Oxide
p.141

Production and Mechanical Properties of Commercial Synthetic Hydroxyapatite (CSHA) Composites
p.147

Nanoparticles for Biomedical Applications Prepared by CO₂ Laser Vaporization
p.154

Fabrication of Magnetic Hydroxyapatite Microcapsule for Protein Collection
p.160

Fabrication of Bioactive Apatite Nuclei Precipitated Polylactic Acid by Using Sandblasting Process
p.165

HomeKey Engineering MaterialsKey Engineering Materials Vol. 587Novel Bioactive Materials neither Based on Calcium...

Novel Bioactive Materials neither Based on Calcium Phosphate Nor Silicate: Titanium Oxide

Abstract:

Various kinds of materials have been found to bond to living bone and some of them are clinically used as important bone substitutes. However, they can not be used under load-bearing conditions, since their fracture toughness are not so high as that of human cortical bone. All of them are based on calcium phosphate or silicate. The present authors recently showed that even Ti metal and its alloys having high fracture toughness can show bone-bonding bioactivity, if they are subjected to simple chemical and heat treatments to form some kind of titanium oxide or titanates on their surfaces. They can show not only bone-bonding property, but also novel functions such as osteoinduction, release of antibacterial or bone-growth promoting ions etc.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 587)

Pages:

141-146

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.587.141

Citation:

Cite this paper

Online since:

November 2013

Authors:

Tadashi Kokubo

Keywords:

Bioactivity, Chemical Treatments, Heat Treatment, Osteoconduction, Osteoinduction, Surface Modification, Ti Alloys, Ti Metal

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] T. Kokubo, H. Takadam, How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 27 (2006) 2907-2915.

DOI: 10.1016/j.biomaterials.2006.01.017

Google Scholar

[2] S. Yamaguchi, H. Takadama, T. Matsushita, T. Nakamura, T. Kokubo, Cross-sectional analysis of the surface ceramic layer developed on Ti metal by NaOH-heat treatment and soaking in SBF, J. Ceram. Soc. Japan, 117 (2009)1126-1130.

DOI: 10.2109/jcersj2.117.1126

Google Scholar

[3] T. Kokubo, S. Yamaguchi, Bioactive Ti metal and its alloys prepared by chemical treatments: State -of-the-art and future trends, Adv. Eng. Mater., 12 (2010) B579-B591.

DOI: 10.1002/adem.201080087

Google Scholar

[4] T. Kizuki, H. Takadama, T. Matsushita, T. Nakamura, T. Kokubo, Effect of contamination on apatite formation on a Ti metal subjected to NaOH and heat treatment, J. Mater. Sci.: Mater. Med. 24 (2013) 635-644.

DOI: 10.1007/s10856-012-4837-6

Google Scholar

[5] T. Kawai, T. Kizuki, H. Takadama, T. Matsushita, H. Unuma, T. Nakamura, T. Kokubo, Apatite formation on surface titanate layer with different Na content on Ti metal, J. Ceram. Soc. Japan 118 (2010) 19-24.

DOI: 10.2109/jcersj2.118.19

Google Scholar

[6] T. Kizuki, H. Takadama, T. Matsushita, T. Nakamura, T. Kokubo, Preparation of bioactive Ti metal surface enriched with calcium ions by chemical treatments, Acta Biomaterialia, 6 (2010) 2836-2842.

DOI: 10.1016/j.actbio.2010.01.007

Google Scholar

[7] S. Yamaguchi, H, Takadama, T. Matsushita, T. Nakamura, T. Kokubo, Apatite-forming ability of Ti-15Zr-4Nb-4Ta alloy induced by calcium solution treatment, J. Mater. Sci.: Mater. Med. 21 (2010) 439-444.

DOI: 10.1007/s10856-009-3904-0

Google Scholar

[8] A. Fukuda, M. Takemoto, T. Saito, S. Fujibayashi, M. Neo, S. Yamaguchi, T. Kizuki, T. Matsushita, M. Niinomi, T. Kokubo, T. Nakamura, Bone bonding bioactivity of Ti metal and Ti-Zr-Nb-Ta alloys with Ca ions incorporated on their surfaces by simple chemical and heat treatments, Acta Biomater., 7 (2011).

DOI: 10.1016/j.actbio.2010.09.026

Google Scholar

[9] S. Yamaguchi, T. Matsushita, T. Kokubo, A bioactive Ti metal with Ca-enriched surface layer releases Mg ions, RSC Advances, 3 (2013) 11274-11282.

DOI: 10.1039/c3ra00054k

Google Scholar

[10] T. Kokubo, D.K. Pattanayak, S. Yamaguchi, H. Takadama, T. Matsushita, T. Kawai, M. Takemoto, S. Fujbayashi, T. Nakamura, Positively charged bioactive Ti metal prepared by simple chemical and heat treatments, J. R. Soc. Interface, 7 (2010).

DOI: 10.1098/rsif.2010.0129.focus

Google Scholar

[11] T. Kawai, M. Takemoto, S. Fujibayashi, M. neo, H. Akiyama, S. Yamaguchi, D.K. Pattanayak, T. Matsushita, T. Nakamura, T. Kokubo, Bone-bonding properties of Ti metal subjected to acid and heat treatments, J. Mater. Sci: Mater. Med. 23 (2012).

DOI: 10.1007/s10856-012-4758-4

Google Scholar

[12] T. Kawai, M. Takemoto, S. Fujibayashi, H. Akiyama, S. Yamaguchi, D K. Pattanayak, K. Doi, T. Matsushita, T. Nakamura, T. Kokubo, S. Matsuda, J. Mater. Sci.: Mater. Med. 24 (2013) 1707-1715.

DOI: 10.1007/s10856-013-4919-0

Google Scholar

[13] D. K. Pattanayak, S. Yamaguchi, T. Matsushita, T. Nakamura and T. Kokubo, Apatite-forming ability of titanium in terms of pH of the exposed solution, J. R. Soc. Interface, 9 (2012) 2145-2155.

DOI: 10.1098/rsif.2012.0107

Google Scholar