Bioactivity of a Poly(70lactic-co-30glycolic acid)/15CaO-85SiO₂ Composite with a Dual Pore Structure

Abstract:

The low crystalline hydroxyl carbonate apatite forming capacity of a poly (70lactic-co-30glycolic acid)/15CaO-85SiO₂ composite, which had a dual pore structure, was newly examined in simulated body fluid. The bioactive 15CaO-85SiO₂ particles were synthesized by a sol-gel method using tetraethyl orthosilicate (TEOS) and calcium nitrate tetrahydrate under acidic condition followed by the heat treatment at 600°C for 3h. The poly (70lactic-co-30glycolic acid)/15CaO-85SiO₂ composite was then prepared by a solvent casting using dimethylformide as a solvent. The composite was loaded into a high pressure chamber and then carbon dioxide gas was introduced achieving a final pressure of 20 MPa. After 3 days, carbon dioxide gas was released quickly and resultantly the dual pore structure was obtained. The samples were observed by FE-SEM and its bioactivity was tested in simulated body fluid.

• Periodical: Key Engineering Materials (Volume 614)
• Pages: 7-10
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.614.7
• Online since: June 2014
• Authors: Hye Young Shin, Sang Hee Shin, Sang Hoon Rhee*
• Keywords: Apatite, Bioactivity, Composite, Poly(70lactic-co-30glycolic acid)

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