Fibers Obtaining and Characterization Using Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene) Containing Hydroxyapatite and α TCP Calcium Phosphate by Electrospinning Method

Abstract:

Natural bone is formed by a complex composite, essentially constituted of biological apatite and fibers of collagen. The combination of materials such as biopolymers and bioceramics may result in an interesting material for application in bone tissue regeneration. This work aims to obtain polymeric fibers containing Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene), supplemented with hydroxyapatite (HA) and α-tricalcium phosphate (TCP). The thermal, mechanical and morphological properties of the fibers were evaluated . Even presenting a larger diameter, fibers with α-TCP presented lower elastic modulus than fibers with HA. Both fibers presented similar thermal behavior, with glass transition temperature in the same range that the one presented by raw PLGA and similar degradation temperatures. Is safe to say that the presence of ceramics in the fibers have a potential for further investigations aiming bone tissue regeneration.

• Periodical: Key Engineering Materials (Volume 631)
• Pages: 173-178
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.631.173
• Online since: November 2014
• Authors: Fernanda Albrecht Vechietti*, D. Marques, Nathália Oderich Muniz, Luis Alberto Santos
• Keywords: Electrospinning, Fiber, Hydroxyapatite (HA), α TCP

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