Collagen/Polyurethane-Coated Bioactive Glass: Early Achievements towards the Modelling of Healthy and Osteoporotic Bone

Abstract:

The development of suitable strategies to treat ageing-related pathologies has attracted the interest of researchers in view of the increasing life expectancy in the next decades. Osteoporosis is a worldwide disease with high prevalence in humans older than 50 that dramatically increases the risk of bone fractures with associated disabilities. The innovative use of new biomaterials as models of the healthy and osteoporotic bone matrix would be a new strategy to study the physiological conditions associated with osteoporosis and the connection between microenvironment changes and the bone ageing process. In this work, experimental bioactive glass substrates were coated with various polymer formulations in order to impart tunable surface features to the whole systems, which will act as models of the healthy and aged bone tissue once they have been colonized by cells.

• Periodical: Key Engineering Materials (Volume 631)
• Pages: 184-189
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.631.184
• Online since: November 2014
• Authors: Silvia Caddeo*, Francesco Baino, Ana Marina Ferreira, Susanna Sartori, Giorgia Novajra, Gianluca Ciardelli, Chiara Vitale-Brovarone
• Keywords: Ageing, Bioactive Glass, Bone, Collagen, Composite, Osteoporosis, Polyurethane, Tissue Engineering

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