Nanostructured Bone Grafting Substitutes Versus Autologous Cancellous Bone – An Animal Experiment in Sheep

Thomas Gerber; Cornelia Ganz; Werner Götz; Kai Helms; Christoph Harms; Thomas Mittlmeier

doi:10.4028/www.scientific.net/KEM.631.202

Paper Titles

Dissolution Behavior of Zinc from Gel Composites Consisting of Calcium Phosphate and Alginate
p.179

Collagen/Polyurethane-Coated Bioactive Glass: Early Achievements towards the Modelling of Healthy and Osteoporotic Bone
p.184

Magnetic Properties of Mg_0.4Ca_0.6Fe₂O₄ Nanoparticles Synthesized by Sol-Gel Method for Hyperthermia Treatment
p.193

Physico-Chemical Characteristics of TiO₂ Derived Nanotube Synthesized by the Hydrothermal Process as a Bioceramic
p.198

Nanostructured Bone Grafting Substitutes Versus Autologous Cancellous Bone – An Animal Experiment in Sheep
p.202

Sintering Behavior of Nanostructured Hydroxyapatite Ceramics
p.207

H₂S Adsorption Capability of Layered Double Hydroxide Containing Transition Metal
p.212

Development and Characterization of Hydroxyapatite Containing Silver by Precipitation and Immersion Methods
p.216

Chemical and Heat Treatments for Inducing Bone-Bonding Ability of Ti-6Al-4V Pedicle Screw
p.225

HomeKey Engineering MaterialsKey Engineering Materials Vol. 631Nanostructured Bone Grafting Substitutes Versus...

Nanostructured Bone Grafting Substitutes Versus Autologous Cancellous Bone – An Animal Experiment in Sheep

Abstract:

In an In vivo study the full synthetic bone substitute NanoBone^® S (NBS) was analyzed using a standardized bone defect (6 x 12 x 24mm) model in the ovine tibial metaphysis. The defect on the left side was filled with NBS granules and on the right side, autologous bone, harvested from the hip of the same animal, was inserted. After six, 12 and 26 weeks sheep were sacrificed and the tibiae analyzed. Quantitative histomorphological analysis after six weeks showed a resorption of biomaterial from over 60 to 24 percent. In contrast the bone formation after 6, and 12 weeks revealed an osteoneogenesis of 19%, and 34%, respectively. Hematoxylin and eosin sections demonstrated multinucleated giant cells on the surface of the biomaterial and resorption lacunae, indicating osteoclastic resorptive activity.

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Periodical:

Key Engineering Materials (Volume 631)

Pages:

202-206

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.631.202

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Online since:

November 2014

Authors:

Thomas Gerber*, Cornelia Ganz, Werner Götz, Kai Helms, Christoph Harms, Thomas Mittlmeier

Keywords:

Autologous Bone Biocompatibility, Bone Substitute, Osteoinduction

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References

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DOI: 10.2106/00004623-198668060-00013

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