Sol-Gel Synthesis and Characterization of SiO₂-CaO-P₂O₅-SrO Bioactive Glass: In Vitro Study

Abstract:

Bioactive glass of the type CaO–SrO–P₂O₅–SiO₂ was obtained by the sol-gel processing method. Three samples containing 0 mol%, 5 mol% and 10 mol% of SrO were synthesized. The obtained bioactive glasses were characterized by the techniques such as, X-ray diffraction (XRD) and scanning electron microscope (SEM) and the effect of SrO/CaO substitution on in vitro biological properties of the synthesized glasses were evaluated and biocompatibility of the samples was measured using MTT assay. The results showed that incorporation of Sr in the obtained glass network did not result in any structural alteration of it due to the similar role of SrO compared with that of CaO. In vitro experiments with human osteosarcoma cell lines (MG-63) and MTT assay indicated that bioactive glass incorporating 5 mol% of Sr in the composition is non-toxic and revealed good biocompatibility.

• Periodical: Key Engineering Materials (Volume 631)
• Pages: 30-35
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.631.30
• Online since: November 2014
• Authors: S. Solgi, M. Shahrezaee, A. Zamanian, T.S. Jafarzadeh Kashi, Majid Raz*, K. Khoshroo, M. Tahriri
• Keywords: Bioactive Glass, Characterization, Sol-Gel, Strontium

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