Investigation of Intermediate Oxidation Products of Genistein and Luteolin Generated in Aerobic Conditions

Victor Khasanov; Svetlana Kravtsova; Konstantin Dychko; Vyacheslav Khasanov

doi:10.4028/www.scientific.net/KEM.670.171

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 670Investigation of Intermediate Oxidation Products...

Investigation of Intermediate Oxidation Products of Genistein and Luteolin Generated in Aerobic Conditions

Abstract:

Unstable intermediate oxidation products in the solution of Luteolin [L] and Genistein [G] were discovered by HPLC-MS-ESI(-) in aerobic conditions at pH=8. These covalently bonded compounds of [2L-H₂] and [L+G-H₂] compositions, as well as trimeric [L+2G-2H₂], can be separated by the HPLC, but easily undergo further destruction. Possibly, such compounds are products of initial radical oxygenation. In trimeric conjugate Luteolin, as a more potent reducing agent, binds two Genistein molecules together.

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Key Engineering Materials (Volume 670)

Pages:

171-176

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.670.171

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Online since:

October 2015

Authors:

Victor Khasanov*, Svetlana Kravtsova, Konstantin Dychko, Vyacheslav Khasanov

Keywords:

Aerobic Oxidation, Dimeric Trimeric Conjugates, Genistein, HPLS-MS, Luteolin

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