Microwave Synthesis of Nanocrystalline Hydroxyapatite and the Application in Bio-Composite

Abstract:

This research synthesized nanocrystalline hydroxyapatite (HA) via microwave assisted heating method. The morphology and crystallinity of nanocrystalline hydroxyapatite were affected by heating power and pH of the mixed solution. Nanocrystalline HA was best obtained when synthesized at pH = 11. Crystal size increased and crystal shape changed from spherical to rod and plate-like when the microwave power was increased from 320 to 800 watts. The synthesized nano-HA could be fabricated into bio-composite films using poly lactic acid (PLA) as the matrix and solvent casting method was utilized. In-vitro study for bioactivity was carried out in the SBF solution which formed hydroxyl-carbonate apatite (HCA) layer on the PLA/nano HA composite surface. The layer thickness increased in the background with increasing soaking time in the SBF.

• Periodical: Key Engineering Materials (Volume 766)
• Pages: 228-232
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.766.228
• Online since: April 2018
• Authors: Pat Sooksaen*, Kamonchanok Mekmork, Teeranuch Limprajuablarp, Sirichoke Kuharuangrong
• Keywords: Composite, Hydroxyapatite, Microwave, Morphology, Nanocrystals

References

[1] D. Shi and X. Wen, Bioactive ceramics: Structure, Synthesis, and Mechanical properties. Introduction to biomaterials: pp.13-28.

[2] H. Arami, M. Mohajerani, M. Mazloumi, R. Khalifehzadeh, A. Lak and S.K. Sadrnezhaad, Rapid formation of hydroxyapatite nanostrips via microwave irradiation. Journal of Alloys and Compounds, 2009. 469: pp.391-394.

DOI: 10.1016/j.jallcom.2008.01.116

[3] R. Nazir, N. Iqbal, A.S. Khan, A. Akram, A. Asif, A.A. Chaudhry, I.U. Rehman and R. Hussain, Rapid synthesis of thermally stable hydroxyapaptite. Ceramics International, 2012. 38: pp.457-462.

DOI: 10.1016/j.ceramint.2011.07.027

[4] J. Liu, K. Li, H. Wang, M. Zhu and H. Yan, Rapid formation of hydroxyapatite nanostructures by microwave irradiation. Chemical Physics Letters, 2004. 396(4–6): pp.429-432.

DOI: 10.1016/j.cplett.2004.08.094

[5] S.J. Kalita and S. Verma, Nanocrystalline hydroxyapatite bioceramic using microwave radiation : synthesis and characterization. Materials Science and Engineering, 2010. C30: pp.295-303.

DOI: 10.1016/j.msec.2009.11.007

[6] S. Bose, S. Dasgupta, S. Tarafder and A. Bandyopadhyay, Microwave-processed nanocrystalline hydroxyapatite: Simultaneous enhancement of mechanical and biological properties. Acta Biomaterialia, 2010. 6: pp.3782-3790.

DOI: 10.1016/j.actbio.2010.03.016

[7] A. Siddharthan, S.K. Seshadri and T.S.S. Kumar, Influence of microwave power on nanosized hydroxyapatite particles. Scripta Materialia, 2006. 55(2): pp.175-178.

DOI: 10.1016/j.scriptamat.2006.03.044

[8] T. Kokubo and H. Takadama, How useful is SBF in predicting in vivo bone bioactivity, Biomaterials, 2006. 27: p.2907–2915.

DOI: 10.1016/j.biomaterials.2006.01.017

[9] Y.Z. Wang and Y. Fu, Microwave-hydrothermal synthesis and characterization of hydroxyapatite nanocrystallites. Materials Letters, 2011. 65: p.3388–3390.

DOI: 10.1016/j.matlet.2011.07.095

[10] P. Sooksaen, N.Pengsuwan, S.Karawatthanaworrakul and S.Pianpraditkul, Formation of Porous Apatite Layer during In Vitro Study of Hydroxyapatite-AW Based Glass Composites, Advances in Condensed Matter Physics, 2015: Article ID:158582, 9 pages.

DOI: 10.1155/2015/158582

[11] N. Olmo, A.I. Martin, A.J. Salinas, J. Turnay, M. A. Lizarbe, Bioactive sol–gel glasses with and without a hydroxycarbonate apatite layer as substrates for osteoblast cell adhesion and proliferation. Biomaterials, 2003. 24: p.3383–3393.

DOI: 10.1016/s0142-9612(03)00200-x