Bioceramics are Not Bioinert: The Role of Oxide and Non-Oxide Bioceramics on the Oxidation of UHMWPE Components in Artificial Joints

Abstract:

The following research is aimed at understanding the influence of Zirconia-Toughened Alumina (ZTA) and Silicon Nitride (Si₃N₄) on Ultra-High Molecular Weight Polyethylene (UHMWPE) acetabular liners. Bioceramic femoral heads were systematically tested against UHMWPE in controlled environment according to static/load-free coupling in hydrothermal environment, pin-on-ball wear testing, and hip-simulator wear testing. In addition, a retrieved ZTA femoral head has been analyzed and results have been compared to the simulations. Experimental results from X-ray photoelectron (XPS), cathodoluminescence (CL), Raman and Fourier-Transformed Infrared spectroscopy suggest that, despite conventional notions imply that bioceramics are inert, the surface chemistry of bioceramics was relevant to the oxidation rate of polyethylene liners. Non-biointertness could either be advantageous or disadvantageous toward polyethylene oxidation. The main reason resides in the peculiar chemical interactions between polyethylene and different ceramics, and, more specifically, depends on the direction of oxygen flow at the interface between the ceramic and the polymer. ZTA femoral heads were found to release a non-negligible amount of oxygen moieties from their surfaces, thus accelerating oxidative degradation of polyethylene. Conversely, Si₃N₄ ceramics exerted a protective role towards the polyethylene liner by scavenging oxygen from the tribolayer. The results of this work provide new insights into the interaction between bioceramics and polymers, which should also be considered when designing the next generation artificial hip joints with significantly elongated lifetimes.

• Periodical: Key Engineering Materials (Volume 782)
• Pages: 165-175
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.782.165
• Online since: October 2018
• Authors: Alfredo Rondinella*, Elia Marin, Bryan McEntire, Ryan Bock, B. Sonny Bal, Wen Liang Zhu, Kengo Yamamoto, Giuseppe Pezzotti
• Keywords: Oxidation, Silicon Nitride, UHMWPE, Wear, ZTA

References

[1] S.R. Knight, R. Aujla, S.P. Biswas, Total Hip Arthroplasty-over 100 years of operative history, Orthopedic reviews 3.2 (2011).

[2] P.S. Christel, Biocompatibility of surgical-grade dense polycrystalline alumina, Clinical orthopaedics and related research, 282 (1992) 10-18.

DOI: 10.1097/00003086-199209000-00003

[3] Australian Orthopaedic Association National Joint Replacement Registry, Annual Report 2015. Available at: https://aoanjrr.sahmri.com/documents/10180/217745/Hip%20and%20Knee% 20Arthroplasty.

[4] Swedish Hip Arthroplasty Register, Annual Report 2013. Available at: https://registercentrum.blob.core.windows.net/shpr/r/Annual-report-2013-HJnnK8Tie.

[5] The New Zealand Joint Registry, Fifteen Year Report: January 1999 to December 2013. Available at: https://nzoa.org.nz/system/files/NZJR2014Report.pdf.

[6] National Joint Registry for England, Wales, and Northern Ireland: 11th Annual Report: 2014. Available at: http://www.njrcentre.org.uk/njrcentre/Portals/0/Documents /England/Reports/11th_annual_report/NJR%2011th%20Annual%20Report%202014.pdf.

[7] G. Willmann, Improving bearing surfaces of artificial joints, Advanced Engineering Materials, 3.3 (2001) 135-141.

DOI: 10.1002/1527-2648(200103)3:3<135::aid-adem135>3.0.co;2-b

[8] H.J. Cho, W.J. Wei, H.C. Kao, C.K. Cheng, Wear behavior of UHMWPE sliding on artificial hip arthroplasty materials, Materials chemistry and physics, 88.1 (2004) 9-16.

DOI: 10.1016/j.matchemphys.2003.10.021

[9] R.C. Dante, C.K. Kajdas, A review and a fundamental theory of silicon nitride tribochemistry, Wear 288 (2012) 27-38.

DOI: 10.1016/j.wear.2012.03.001

[10] E.M.B. Del Prever, A. Bistolfi, P. Bracco, L. Costa, UHMWPE for arthroplasty: past or future?, Journal of Orthopaedics and Traumatology 10.1 (2009) 1-8.

DOI: 10.1007/s10195-008-0038-y

[11] G. Pezzotti, S.B. Bal, E. Casagrande, N. Sugano, B.J. McEntire, W. Zhu, L. Puppulin, On the molecular interaction between femoral heads and polyethylene liners in artificial hip joints: phenomenology and molecular scale phenomena, Biomedical Materials, 12.1 (2016).

DOI: 10.1088/1748-605x/12/1/015005

[12] S. Affatato, B. Bordini, C. Fagnano, P. Taddei, A. Tinti, A. Toni, Effects of the Sterilisation Method on the Wear of UHMWPE Acetabular Cups Tested in a Hip Joint Simulator, Biomaterials, 23.6 (2002) 1439-1446.

DOI: 10.1016/s0142-9612(01)00265-4

[13] G. Pezzotti, Raman Spectroscopy of Biomedical Polyethylenes, Acta biomaterialia 55 (2017) 28-99.

DOI: 10.1016/j.actbio.2017.03.015

[14] S.M. Kurtz, O.K. Muratoglu, F.J. Buchanan, B. Currier, R. Gsell, F.W. Shen, S.S. Yau, Interlaboratory studies to determine optimal analytical methods for measuring the oxidation index of UHMWPE, Biomaterials 22.21 (2001) 2875-2881.

DOI: 10.1016/s0142-9612(01)00033-3

[15] D.E. King, W.E. Swartz, Variable-angle X-ray photoelectron spectroscopic determination of the thickness of the oxide layer on aluminum metal: An advanced undergraduate laboratory experiment, Journal of Chemical Education 64.11 (1987) 981.

DOI: 10.1021/ed064p981

[16] C.D. Wagner, D.E. Passoja, H.F. Hillery, T.G. Kinisky, H.A. Six, W.T. Janser, J.A. Taylor. Auger and photoelectron line energy relationships in aluminum–oxygen and silicon–oxygen compounds, Journal of Vacuum Science and Technology 21.4 (1982).

DOI: 10.1116/1.571870

[17] J.R. Lindsay, H.J. Rose, W.E. Swartz, P.H. Watts, K.A. Rayburn, X-ray photoelectron spectra of aluminum oxides: structural effects on the chemical shift,, Applied Spectroscopy 27.1 (1973) 1 - 5.

DOI: 10.1366/000370273774333876

[18] B.G. Draeger, G.P. Summers, Defects in Unirradiated α-Al2O3, Physical Review B 19.2 (1979) 1172.

[19] K.H. Lee, J.H. Crawford, Luminescence of the F Center in Sapphire, Physical review B 19.6 (1979) 3217.

[20] G. Pezzotti, E. Marin, T. Adachi, A. Rondinella, F. Boschetto, W. Zhu, N. Sugano, R.M. Bock, B. McEntire, S.B. Bal, Bioactive silicon nitride: A new therapeutic material for osteoarthro-pathy, Scientific Reports 7 (2017) 44848.

DOI: 10.1038/srep44848

[21] T. Sekiguchi, K. Sumino, Cathodoluminescence study on dislocations in silicon, Journal of applied physics, Journal of applied physics 79.6 (1996) 3253-3260.

DOI: 10.1063/1.361271

[22] I..J. Leslie, S. Williams, G. Isaac, E. Ingham, J. Fisher, High Cup Angle and Microseparation Increase the Wear of Hip Surface Replacements, Clinical Orthopaedics and Related Research® 467.9 (2009) 2259-2265.

DOI: 10.1007/s11999-009-0830-x

[23] C. Kajdas, General Approach to Mechanochemistry and Its Relation to Tribochemistry, Tribology in engineering, InTech, (2013).

DOI: 10.5772/50507