Development of Titanium Implants with a Rough Calcium Phosphate Surface to Control the Morphofunctional State of Stem Cells

Abstract:

Experimental titanium implants with a rough calcium phosphate (CР) coating with bio-inspired properties have been developed. The role of roughness (in the range Ra = 2.4 - 4.6 μm) of the surface CP simulating the physicochemical features of the mineral substance of regenerating bone tissue to change the growth and morphofunctional activity of mesenchymal stem cells (MSCs) was evaluated. Titanium substrates with a microrelief CP coating bearing artificial niches for stem cells was shown in vitro to have an epigenomic effect on MSCs, that contributes to their differentiation and maturation in bone cells. The results show the promise of developing and introducing a new class of medical devices with bio-inspired surfaces into clinical practice for traumatology and orthopedics.

• Periodical: Key Engineering Materials (Volume 887)
• Pages: 40-45
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.887.40
• Online since: May 2021
• Authors: K.A. Yurova*, Igor A. Khlusov, L.S. Litvinova
• Keywords: Human Adipose Tissue, Mesenchymal Stem Cells, Micro-Arc Calcium Phosphate Coating, Microrelief

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