Effect of Sintered Magnesium Substituted Biphasic Calcium Phosphate (Mg-BCP)

Abstract:

Biphasic Calcium Phosphate (BCP) is a ceramic material that consisting of two phases which is Hydroxyapatite (HA) and β-Tricalcium Phosphate (β-TCP). In this work, BCP and Mg-BCP (Mg Doped) was synthesized using aqueous precipitation method at standard room temperature and pressure. The synthesized powder was pressed into pellet and sintered at three consecutive temperatures of 800 °C, 900 °C, and 1000 °C. The sintered pellet was characterized using XRD to obtained the quantification analysis on phases presence and to study the crystal orientation of HA and β-TCP before and after Mg doping was introduced. FTIR was used to determine chemical constituents of synthesized powders. Diameter shrinkage analysis was performed to study the effect of temperatures on the densification of the pellet body and SEM was used to observed the morphology of each pellet. Based on the XRD result, the Mg doping is affecting the stability of the phases presence and the crystal lattice creating a distortion due to the substitution of smaller Mg ion. Analysis on the SEM morphology have shown that Mg doped BCP resulting a dense structure with less formation of porosity, necking was formed clearly at temperatures of 900 °C to 1000 °C.

• Periodical: Materials Science Forum (Volume 1010)
• Pages: 567-572
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1010.567
• Online since: September 2020
• Authors: M.H.M. Marahat*, Hasmaliza Mohamad, Shah Rizal Kasim
• Keywords: Biomaterial, Biphasic Calcium Phosphate, Densification, Magnesium Doped

References

[1] S. Teixeira, H. Fernandes, A. Leusink, C. Van Blitterswijk, MP. Ferraz, FJ. Monteiro, J. de Boer, In-vivo evaluation of highly macroporous ceramic scaffolds for bone tissue engineering, J. Biomed. Mater. Res. A, (2010), 93(2), p.567–575.

DOI: 10.1002/jbm.a.32532

[2] ES. Thian, T. Konishi, Y. Kawanobe, PN. Lim, C. Choong, B. Ho, M. Aizawa, Zinc-substituted hydroxyapatite: A biomaterial with enhanced bioactivity and antibacterial properties, J. Mater. Sci. Mater. Med., (2013), 24(2), p.437–445.

DOI: 10.1007/s10856-012-4817-x

[3] J.I. González Ocampo, D.M Escobar Sierra, and C.P Ossa Orozco, Porous bodies of hydroxyapatite produced by a combination of the gel-casting and polymer sponge methods, J. Adv. Res., (2016) 7(2), p.297–304.

DOI: 10.1016/j.jare.2015.06.006

[4] N. Eliaz, and N. Metoki, Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications, Materials, MDPI AG, (2017), 10(4), p.334.

DOI: 10.3390/ma10040334

[5] K.W. Kim, H.S. Lee, D.H. Kim, H.H. Jin, K.H. Hwang, J.K. Lee, H.C. Park, S.Y. Yoon, In situ synthesis of magnesium-substituted biphasic calcium phosphate and in vitro biodegradation, Materials Research Bulletin, Elsevier BV, (2012), 47(9), p.2506–2512.

DOI: 10.1016/j.materresbull.2012.05.011

[6] L. Galea, M. Bohner, J. Thuering, N. Doebelin, T.A. Ring, C.G. Aneziris, T. Graule, Growth kinetics of hexagonal sub-micrometric β-tricalcium phosphate particles in ethylene glycol, Acta Biomater., (2014), 10(9), pp.3922-3930.

DOI: 10.1016/j.actbio.2014.02.044

[7] J. Tao, W. Jiang, H. Zhai, H. Pan, X. Xu and R. Tang, Structural components and anisotropic dissolution behaviors in one hexagonal single crystal of β-tricalcium phosphate,, Crystal Growth & Design, American Chemical Society (ACS), (2008) 8(7), p.2227–2234.

DOI: 10.1021/cg700808h

[8] S. Roopalakshmi, R. Ravishankar, S. Belaldavar, R.G.S.V. Prasad, A.R. Phani, Investigation of Structural and Morphological Characteristic of Hydroxyapatite Synthesized by Sol-Gel Process, Materials Today: Proceedings, Elsevier BV, (2017), 4(11), p.12026–12031.

DOI: 10.1016/j.matpr.2017.09.126