Paper Titles
Experimental Research on Submerged Underwater Friction Stir Processing of EN AW 1200 Aluminum Alloy
p.35
Submerged Friction Stir Processing of En Aw 5754 Aluminum Alloy
p.45
Aspects of Fracture Surface Analysis of Aluminum Alloy EN AW 6082 Submerged Friction Stir Processed
p.55
Fracture Surface Analysis of EN AW 5754 Aluminium Alloy during Submerged Friction Stir Processing
p.65
Development and Characterization of a Curcumin-Loaded Alginate-Xanthan Gum Hydrogel for Antibacterial Activity and Controlled Drug Release
p.79
Beta-Cyclodextrin Inclusion Complexes of Rose Oil and Rose Extract: Preparation and Physical Properties
p.87
Compressive Strength Assessment of Polymer- Soilcrete Blocks for Sustainable Mass Housing
p.99
Durability Scrutiny and Performance Prediction of Geopolymer Concrete Containing Bespoke Activator and Superplasticizer
p.111
Influence of Redispersible Polymer Type and Content on Restrained Shrinkage Cracking in Non-Structural Concrete Patch Repair Mortars
p.123

Development and Characterization of a Curcumin-Loaded Alginate-Xanthan Gum Hydrogel for Antibacterial Activity and Controlled Drug Release

Article Preview

Abstract:

This article describes the development and characterization of a curcumin-loaded alginate-xanthan gum hydrogel, designed to provide both antibacterial activity and controlled drug release.The hydrogel formulation consisted of 4% (w/v) alginate, 4% (w/v) xanthan gum, and 500 μg/mL of curcumin. Sterilization was achieved through ethanol immersion, UV irradiation, and autoclaving, with the latter two methods proving to be the most effective in maintaining long-term sterility. Antibacterial efficacy was tested against Staphylococcus aureus, demonstrating a significant inhibition zone around the hydrogel. The curcumin release profile indicated a sustained release over 72 hours, suggesting its suitability for prolonged antibacterial applications.

You might also be interested in these eBooks
Materials Properties, Processing and Application View Preview

Info:

Periodical:

Materials Science Forum (Volume 1161)

Pages:

79-85

DOI:

https://doi.org/10.4028/p-vEt8Dm

Citation:

Cite this paper

Online since:

October 2025

Authors:

Lizardo Torres*, Sofia Cespedes, Suyeon Kim, Javier Nakamatsu, Marco Obregón Príncipe, Denis Castillo

Keywords:

Alginate, Antibacterial Activity, Curcumin, Drug Release, Hydrogel, Xanthan Gum

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2025 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

References

[1] Martina Vigata, Christoph Meinert, Dietmar W. Hutmacher, and Niels Bock. Hydrogels as drug delivery systems: A review of current characterization and evaluation techniques. Pharmaceu- tics, 12(12):1188, 2020.

DOI: 10.3390/pharmaceutics12121188

Google Scholar

[2] Mayur Jadav, Deepika Pooja, David J. Adams, and Harish Kulhari. Advances in xanthan gum- based systems for the delivery of therapeutic agents. Pharmaceutics, 15(2):402, 2023.

DOI: 10.3390/pharmaceutics15020402

Google Scholar

[3] Eneko Larrañeta, Sarah A. Stewart, Michael Ervine, Rehan Al-Kasasbeh, and Ryan F. Donnelly. Hydrogels for hydrophobic drug delivery. classification, synthesis and applications. Journal of Functional Biomaterials, 9, 2018.

DOI: 10.3390/jfb9010013

Google Scholar

[4] Mohammadmahdi Mobaraki, Davood Bizari, Madjid Soltani, Hadi Khshmohabat, Kaamran Raahemifar, and Mehdi Akbarzade Amirdehi. The effects of curcumin nanoparticles incor- porated into collagen-alginate scaffold on wound healing of skin tissue in trauma patients. Poly- mers, 13, 12 2021.

DOI: 10.3390/polym13244291

Google Scholar

[5] Bharat B Aggarwal, Subash C Gupta, and Bokyung Sung. Theme section: Emerging therapeutic aspects in oncology curcumin: an orally bioavailable blocker of tnf and other pro-inflammatory biomarkers. Br J Pharmacol, 169, 2013.

DOI: 10.1111/bph.12131

Google Scholar

[6] Ping Zhou, Hao Zhou, Jian Shu, Shaozhi Fu, and Zhu Yang. Skin wound healing promoted by novel curcumin-loaded micelle hydrogel. Annals of Translational Medicine, 9:1152–1152, 7 2021.

DOI: 10.21037/atm-21-2872

Google Scholar

[7] Yasir Hussain, Waqas Alam, Haroon Ullah, Maurizio F. Dacrema, Maria Daglia, Haroon Khan, and Carla Renata Arciola. Antimicrobial potential of curcumin: Therapeutic potential and chal- lenges to clinical applications. Antibiotics, 11(3):322, 2022.

DOI: 10.3390/antibiotics11030322

Google Scholar

[8] Kuen Yong Lee and David J. Mooney. Alginate: Properties and biomedical applications. Progress in Polymer Science, 37(1):106–126, 2012.

DOI: 10.1016/j.progpolymsci.2011.06.003

Google Scholar

[9] Junyan Tan, Yuning Luo, Yuqiong Guo, Yue Zhou, Xinying Liao, Dingxilei Li, Xinyi Lai, and Yang Liu. Development of alginate-based hydrogels: Crosslinking strategies and biomedical applications. International Journal of Biological Macromolecules, 239:124275, 2023.

DOI: 10.1016/j.ijbiomac.2023.124275

Google Scholar

[10] Mohamed A.S. Abourehab, Ritesh R. Rajendran, Akanksha Singh, Satya Pramanik, Prashant Shrivastav, Mohd Javed Ansari, Ravi Manne, Luis S. Amaral, and Akshay Deepak. Alginate as a promising biopolymer in drug delivery and wound healing: A review of the state-of-the-art. International Journal of Molecular Sciences, 23(16):9035, 2022.

DOI: 10.3390/ijms23169035

Google Scholar

[11] Kun Wang, Jie Sui, Wei Gao, Bin Yu, Chao Yuan, Li Guo, Bo Cui, and A.M. Abd El-Aty. Effects of xanthan gum and sodium alginate on gelatinization and gels structure of debranched pea starch by pullulanase. Food Hydrocolloids, 130:107733, 2022.

DOI: 10.1016/j.foodhyd.2022.107733

Google Scholar

[12] Cinzia Pagano, Debora Puglia, Francesca Luzi, Alessandro Di Michele, Stefania Scuota, Sara Primavilla, Maria Rachele Ceccarini, Tommaso Beccari, César Antonio Viseras Iborra, Daniele Ramella, Maurizio Ricci, and Luana Perioli. Development and characterization of xanthan gum and alginate based bioadhesive film for pycnogenol topical use in wound treatment. Pharma- ceutics, 13(3), 2021.

DOI: 10.3390/pharmaceutics13030324

Google Scholar

[13] Ramesh C. Garg, Vinod Kumar, and Vandana Sharma. Design and characterization of flucyto- sine loaded bioadhesive in situ ophthalmic gel for improved bioavailability. 2019.

DOI: 10.20510/ukjpb/7/i6/1581754222

Google Scholar

[14] Prerna Chansoria, Lakshmi K. Narayanan, Molly Wood, Caroline Alvarado, Angela Lin, and Rahul A. Shirwaiker. Effects of autoclaving, etoh, and uv sterilization on the chemical, mechan- ical, printability, and biocompatibility characteristics of alginate. ACS Biomaterials Science & Engineering, 6(9):5191–5201, September 2020. Epub 2020 Jul 31.

DOI: 10.1021/acsbiomaterials.0c00806

Google Scholar

[15] Yingjun Gao, Xing Zhang, and Xiangyu Jin. Preparation and properties of minocycline-loaded carboxymethyl chitosan gel/alginate nonwovens composite wound dressings. Marine Drugs, 17(10):575, 2019.

DOI: 10.3390/md17100575

Google Scholar

[16] Sandhuli S. Hettiarachchi, Yohanka Perera, Shashiprabha P. Dunuweera, Asiri N. Dunuweera, Sanath Rajapakse, and Gamini R. Rajapakse. Comparison of antibacterial activity of nanocur- cumin with bulk curcumin. ACS Omega, 7(50):46494–46500, 2022.

DOI: 10.1021/acsomega.2c05293

Google Scholar