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Detection of Hepatitis D Virus in Human Blood Serum Using Surface Plasmon Resonance in Gold Film
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Detection of Hepatitis D Virus in Human Blood Serum Using Surface Plasmon Resonance in Gold Film

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Abstract:

Mongolia is one of the countries with the highest prevalence of Hepatitis Delta Virus (HDV). A 2023 study showed that in rural areas of Mongolia, the HDV prevalence rate was 65%. Therefore, implementing low-cost diagnostic methods for early detection of HDV in Mongolia would be important. A novel setup was designed and assembled, using Surface Plasmon Resonance (SPR), to measure the spectra minimums of gold thin film which contained four samples, including HDV-positive and HDV-negative serum. Relative to gold thin film and antigen, HDV-negative and HDV-positive samples exhibited a shift in the SPR spectra minimum. These results demonstrate that this SPR effect could serve as a relatively rapid and cost-effective diagnostic method for detecting the presence of HDV in blood serum samples on gold thin film surfaces.

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Info:

Periodical:

Materials Science Forum (Volume 1165)

Pages:

143-148

DOI:

https://doi.org/10.4028/p-l38DlP

Citation:

Cite this paper

Online since:

November 2025

Authors:

Batzul Ganbold*, Galbadrakh Ragchaa, Bolorchimeg Jamsran, Naranbat Baasankhuu, Chultem Batsukh, Temujin Enkhbat, Odgerel Oidovsambuu, Jav Davaasambuu

Keywords:

Gold Thin Film, Hepatitis D Virus, Surface Plasmon Resonance Biosensor

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© 2025 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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