Human Platelet Extracts Stimulate the Terminative Differentiation of Growth-Plate Chondrocytes in Rabbit

Li Yu; Ming Qiao Tang; Wei Qun Yan

doi:10.4028/www.scientific.net/MSF.610-613.1070

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Human Platelet Extracts Stimulate the Terminative Differentiation of Growth-Plate Chondrocytes in Rabbit
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Human Platelet Extracts Stimulate the Terminative Differentiation of Growth-Plate Chondrocytes in Rabbit

Abstract:

Objective：To observe the effect of human platelet extracts on proliferation and differentiation of rabbit growth-plate chondrocytes in monolayer and fabrication of tissue engineering cartilage in vitro. Method: To determine the effects of platelet extracts at different concentrations on proliferation and differentiation of rabbit growth-plate chondrocytes using 3H-TdR、PNP and HE staining. Results: Platelet extracts had very strong stimulative effects on proliferation and differentiation of chondrocytes, especially the hypertropization (termination) of chondrocytes.