Human Platelet Extracts Stimulate the Terminative Differentiation of Growth-Plate Chondrocytes in Rabbit
Objective：To observe the effect of human platelet extracts on proliferation and differentiation of rabbit growth-plate chondrocytes in monolayer and fabrication of tissue engineering cartilage in vitro. Method: To determine the effects of platelet extracts at different concentrations on proliferation and differentiation of rabbit growth-plate chondrocytes using 3H-TdR、PNP and HE staining. Results: Platelet extracts had very strong stimulative effects on proliferation and differentiation of chondrocytes, especially the hypertropization (termination) of chondrocytes.
Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
L. Yu et al., "Human Platelet Extracts Stimulate the Terminative Differentiation of Growth-Plate Chondrocytes in Rabbit", Materials Science Forum, Vols. 610-613, pp. 1070-1075, 2009