Nano energetic materials (nEMs) have improved performance in energy release, ignition, and mechanical properties compared to their bulk or micro counterparts. In this study a micro fuse developed by intergrating Al/CuO-based nanoenergetic materials on a micro wire. CuO nanowires are synthesized by thermally annealing Cu film deposited onto a micro wire. Nano-Al is integrated with the nanowires by thermal to realize an Al/CuO based nEMs. It allows batch and high level of integration and reliability. The micro fuse is tested by open-air combustion testing and characterized by scanning electron microscopy, x-ray diffraction, differential thermal analysis and differential scanning calorimetry.