Freeze-Drying and Characterization of Vitamin a Palmitate-Loaded Nanostructured Lipid Carriers (NLC)

Qiang Xia; Rong Kong

doi:10.4028/www.scientific.net/MSF.694.365

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HomeMaterials Science ForumMaterials Science Forum Vol. 694Freeze-Drying and Characterization of Vitamin a...

Freeze-Drying and Characterization of Vitamin a Palmitate-Loaded Nanostructured Lipid Carriers (NLC)

Abstract:

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique. Trehalose, glucose, mannitol, α-lactin, D-sorbitol, D-maltose monohydrate and sucrose were chosen as the cryoprotectants. Also, the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively. Glucose and α-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process. The most suitable concentrations were proved to be 5 wt% and 5 wt%, respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying. In conclusion, the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry.

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Periodical:

Materials Science Forum (Volume 694)

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365-369

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.694.365

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Online since:

July 2011

Authors:

Qiang Xia, Rong Kong

Keywords:

Cryoprotectants, High-Pressure Homogenization, Lyophilisation, Nanostructured Lipid Carriers, Vitamin A Palmitate

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