Osteoblast Ingrowth into Titanium Scaffolds Made by Electron Beam Melting

Abstract:

Present paper describes early findings from the study of Ti-6Al-4V scaffolds additively manufactured using electron beam melting (EBM^®) technology and the influence of surface topography on the initial stages of cell acceptance. The surface topography of the components made by additive manufacturing (AM) processes including EBM^® are often hard to control within the desired feature size range without post-processing. Two groups of experiments studying the behavior of human osteoblast-like cells (MG63) on samples with different surface roughness were carried out in vitro: Ti-6Al-4V samples only powder-blasted, and Ti-6Al-4V samples additionally electrochemically polished. The cell migration into powder-blasted Ti-6Al-4V 3D scaffolds with different shapes and dimensions of the lattice structures were studied.

• Periodical: Materials Science Forum (Volumes 783-786)
• Pages: 1292-1297
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.783-786.1292
• Online since: May 2014
• Authors: Andrey Koptioug*, Claudia Bergemann, Regina Lange, Victor Emanuel Jaggi, Lars Erik Rännar, J. Barbara Nebe
• Keywords: 3D Cell Culture, Additive Manufacturing (AM), Biocompatibility, Electron Beam Melting, Osteoblastic Cells, RT-PCR, Scaffold, Surface Roughness (SR), Titanium

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