Fabrication and Characteristics of Gene-Delivering Nanodevices Based on Au-Ag@CS-FA Hybrid Particles

Qing Wen Guan; Min Wang

doi:10.4028/www.scientific.net/MSF.815.401

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Particle Size of 45S5 Bioactive Glass Affected the Enamel Remineralization
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Excellent Cell Compatibility in Time Controlled Silk Fibroin Hydrogels
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Matrix Elasticity Affects Integrin Expression in Human Umbilical Cord-Derived Mesenchymal Stem Cells
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HomeMaterials Science ForumMaterials Science Forum Vol. 815Fabrication and Characteristics of Gene-Delivering...

Fabrication and Characteristics of Gene-Delivering Nanodevices Based on Au-Ag@CS-FA Hybrid Particles

Abstract:

Gene therapy has great potential in offering highly promising treatments for cancer. Polymer-metal hybrid nanoparticles (NPs) are good candidates as gene delivery vehicles due to their unique properties and facile functionalization. The polymer component in hybrid NPs can provide accurate cancer cell targeting and high DNA binding ability while the metallic component can provide imaging functions for the nanodevices. In the present study, hybrid NPs comprising an Au-Ag bimetallic core and a folic acid-chitosan shell (Au-Ag@CS-FA) were fabricated. The structure and relevant properties of Au-Ag@CS-FA NPs were subsequently studied using a variety of techniques,like scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), transmission electron microscope (TEM) and UV-visible spectra. Their DNA binding ability was also assessed. Results showed that Au-Ag@CS-FA NPs possessed properties that can make them excellent gene delivery vehicles.

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Periodical:

Materials Science Forum (Volume 815)

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401-406

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.815.401

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Online since:

March 2015

Authors:

Qing Wen Guan, Min Wang*

Keywords:

Au-Ag Nanoparticle, Chitosan, Folic Acid, Gene Delivery, Hybrid Nanoparticle

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