Preparation of Collagen/Hydroxyapatite Composite Coating on Porous Titanium Substrate and its Cellular Response

Abstract:

In this article, the layered deposition method is adopted to prepare the collagen/hydroxyapatite (COL/HA) composite coating. The morphology and elements of the COL/HA composite coating are observed using a scanning electron microscope (SEM) with an energy dispersive spectrometer (EDS), the optical density (O.D.) values are obtained by MTT assay to assess the cellular viabilityof composite coating. The experimental results showed that the addition of collagen not only improve the bonding strength of composite coating and porous titanium substrate, but also combine the osteoconduction of inorganic coating HA and the osteoinduction of organic coating COL, effectively enhance the cellular adhesion, proliferation and differentiation. The cellular viability cultured in COL/HA composite coating is much higher than the pure HA modified coating.

• Periodical: Materials Science Forum (Volume 815)
• Pages: 429-433
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.815.429
• Online since: March 2015
• Authors: Ting Li, Jin Shan Li, Hong Chao Kou, Fu Ping Li, Ting Li Lu
• Keywords: Cellular Response, COL/Ha Composite Coating, Porous Titanium

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