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HomeMaterials Science ForumMaterials Science Forum Vol. 852Protein Release and Biological Evaluation of...

Protein Release and Biological Evaluation of Bio-Inspired Chitosan-Based Nano-Gels

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Abstract:

Bio-inspired nanogels were prepared by ionically crosslinking sodium tripolyphosphate (TPP) and biomimetic phosphorylcholine-chitosan derivative (PCCs) which was synthesized from chitosan and cell membrane-mimicking phosphorylcholine. The physcochemical properties of PCCs/TPP nanogels were investigated by dynamic laser scattering and transmission electron microscopy, as well as their hemocompatibility were tested. Bovine serum albumin was used as a model protein to study protein adsorption, loading and releasing property of these nanogels in vitro. The results indicated that biomimetic PCCs/TPP nanogels can not only restrain the non-specific protein adsorption, improve the hemocompatibility, but also have good loading and releasing protein efficacy, which will be a promising nanocarrier for protein drug delivery.

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Functional Materials Research

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Periodical:

Materials Science Forum (Volume 852)

Pages:

1313-1318

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.852.1313

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Online since:

April 2016

Authors:

Fang Min Situ, Hong Wei Dong, Min Ming Wu, Kai Guo, Rong Zeng, Mei Tu, Jian Hao Zhao

Keywords:

Biomimetic, Chitosan, Nano-Gel, Protein

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© 2016 Trans Tech Publications Ltd. All Rights Reserved

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