Application of Chitosan as Scaffold Material of Construction In Vitro

Abstract:

Tissue engineering has the potential to regenerate tissue which regeneration capacity is limited. Nowadays, three-dimensional scaffold has become an excellent scaffold in tissue engineering. Chitosan as a scaffold material in tissue engineering is known for emerging techniques for treating some tissue damage, but there are questions that need to be answered, including application of chitosan and other materials, to provide growth factors, mechanical support and other micro environment, as well as the application at all levels, including conducive to an optimal and suitable cell source, the usability of growth factor, the selectivity of optimal biomaterial scaffolds as well as the technology for improving partial reconstruction of meniscus tears. This review focuses on current research on application of chitosan as scaffold material of construction In Vitro.

• Periodical: Materials Science Forum (Volume 893)
• Pages: 53-56
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.893.53
• Online since: March 2017
• Authors: Yu Zhang, Peng Song Li, Dao Yu Chen, Hai Chao Dong, Jing Jing Zhang, Mei Ling Zhuang, Ke Dong Song, Tian Qing Liu
• Keywords: Chitosan, Construction, In Vitro, Scaffold, Tissue Engineering

References

[1] Gowran, A., et al., Tissue Engineering of Cartilage; Can Cannabinoids Help? Pharmaceuticals (Basel), 2010. 3(9): pp.2970-2985.

DOI: 10.3390/ph3092970

[2] Rodriguez-Vazquez, M., et al., Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine. Biomed Res Int, 2015. 2015: p.821279.

[3] Gu, Y., et al., Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps. Biomaterials, 2014. 35(7): pp.2253-63.

DOI: 10.1016/j.biomaterials.2013.11.087

[4] Sun, Y., Q. Yang, and H. Wang, Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering. J Funct Biomater, 2016. 7(3).

[5] Gomathysankar, S., A.S. Halim, and N.S. Yaacob, Proliferation of keratinocytes induced by adipose-derived stem cells on a chitosan scaffold and its role in wound healing, a review. Arch Plast Surg, 2014. 41(5): pp.452-7.

DOI: 10.5999/aps.2014.41.5.452

[6] Krajewska, B., Membrane-based processes performed with use of chitin/chitosan materials. Separation and Purification Technology, 2005. 41(3): pp.305-312.

DOI: 10.1016/j.seppur.2004.03.019

[7] Luo, H., J. Li, and X. Chen, Potential role of N-Succinyl-Chitosan in immune reconstitution after umbilical cord blood transplantation in mice. Biomedicine & Pharmacotherapy, 2011. 65(8): pp.578-584.

DOI: 10.1016/j.biopha.2010.01.011

[8] Skop, N.B., et al., Heparin crosslinked chitosan microspheres for the delivery of neural stem cells and growth factors for central nervous system repair. Acta Biomater, 2013. 9(6): pp.6834-43.

DOI: 10.1016/j.actbio.2013.02.043

[9] Sivashankari, P.R. and M. Prabaharan, Prospects of chitosan-based scaffolds for growth factor release in tissue engineering. International Journal of Biological Macromolecules.

DOI: 10.1016/j.ijbiomac.2016.02.043

[10] Yu, P., et al., Self-assembled high-strength hydroxyapatite/graphene oxide/chitosan composite hydrogel for bone tissue engineering. Carbohydrate Polymers, 2017. 155: pp.507-515.

DOI: 10.1016/j.carbpol.2016.09.001

[11] Muthukumar, T., et al., Collagen/chitosan porous bone tissue engineering composite scaffold incorporated with Ginseng compound K. Carbohydrate Polymers, 2016. 152: pp.566-574.

DOI: 10.1016/j.carbpol.2016.07.003