Structure and Properties of Fibrous Materials Based on Poly(-3-Hydroxybutyrate)

Abstract:

The article studies the supramolecular structure of polymer matrices for sustained isolation of drugs based on ultrathin fibers of polyhydroxybutyrate obtained by electrospinning method. Dipyridamole was chosen as a model drug. The concentration of dipyridamole in the fibers ranged from 1 to 5%. The morphology of nonwoven fibrous materials was investigated by scanning electron microscopy, differential scanning calorimetry, electron paramagnetic resonance. It was shown that the addition of the dipyridamole leads to a change in the fiber geometry. Fibers based on polyhydroxybutyrate are characterized by non-equilibrium molecular structure. In the current work, it was found that the addition of dipyridamole causes extra crystallization processes and the molecular mobility in the amorphous regions of the polymer slows down

• Periodical: Materials Science Forum (Volume 992)
• Pages: 375-379
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.992.375
• Online since: May 2020
• Authors: Anatoly A. Olkhov*, P.M. Tyubaeva, A.L. Iordansky
• Keywords: Complex of Tetraphenylporphyrin with the Iron, Dipyridamole, Electrospinning, Implants, Polyhydroxybutyrate, Sustained Release Matrix, Ultrathin Fibers

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