Phage Display - A Promising Tool for the Recovery of Valuable Metals from Primary and Secondary Resources

Abstract:

The development of effective and ecofriendly processes for the recovery of critical elements poses a challenge for scientists all over the world. A novel approach is the generation of highly specific peptides that bind with high affinity to individual elements of interest. The peptides are selected by phage surface display (PSD) technology. In this study, PSD technology has been applied in two different approaches. The focus of the first approach was the identification of peptides that bind specifically to special particles of interest that are part of electronic scrap aiming towards the development of new recycling processes. In the second approach, metal ion binding peptides were isolated via PSD to use them for the targeted removal and enrichment of these elements from complex leaching solutions or from industrial waters. To address the economic production of peptides, the development of a new expression system is also part of this study.

• Periodical: Solid State Phenomena (Volume 262)
• Pages: 443-446
• DOI: https://doi.org/10.4028/www.scientific.net/SSP.262.443
• Online since: August 2017
• Authors: Sabine Matys*, Franziska L. Lederer, Nora Schönberger, Robert Braun, Falk Lehmann, Katrin Flemming, Stefanie Bachmann, Susan Curtis, Ross T.A. MacGillivray, Katrin Pollmann
• Keywords: Bacteriophage, Bioflotation, Biosorption, Co-Ions, Fluorescent Phosphor, Ga-Ions, Heterologous Peptide Expression, Ni-Ions

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