Synthesis and Evalution of Enteric Aqueous Polymethacrylate Coating Material

Abstract:

A kind of enteric-coated pharmaceutical coating material, which can be dissolved in pH>5.5 medium, was successfully prepared by pre-emulsionsemi-continuous polymerization methods with equal molecular mass of methacrylic acid and ethyl acrylate as main raw materials. The effects of the initiator and chain transfer agent on the molecular weight and the performance of the emulsion were discussed. The obtained compound was used as the coating material of Lansoprazole capsule, and the dissolution rate was measured. The results show that polymethacrylat emulsion with 1.83×10⁵ of molecular weight was obtained when the dosage of the initiator and the chain transfer agent is 0.43% and 0.79% of the total monomer mass, respectively. The dissolution rate of Lansoprazole capsule coated polymethacrylat emulsion in the pH 6.8 medium was greater than 75%.

• Periodical: Applied Mechanics and Materials (Volume 483)
• Pages: 56-60
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.483.56
• Online since: December 2013
• Authors: Xiao Qi Chen, Chao Liu, Hai Jun Zhou, Xiao Lei Zhang, Fei Wang, Yan Tao Li*
• Keywords: Dissolution, Enteric, Methacrylic Acid, Relative Molecular Weight

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