Synthesis of d4T- 5′-glycosyl-1″-phosphoramidates from H-Phosphonates via an Oxidative Coupling Strategy

Shan Shan Gong; Guo Dong Liu; Qing Kun Yang; Qi Sun

doi:10.4028/www.scientific.net/AMM.483.79

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Synthesis of d4T- 5′-glycosyl-1″-phosphoramidates from H-Phosphonates via an Oxidative Coupling Strategy
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 483Synthesis of d4T- 5′-glycosyl-1″-phosphoramidates...

Synthesis of d4T- 5′-glycosyl-1″-phosphoramidates from H-Phosphonates via an Oxidative Coupling Strategy

Abstract:

An improved synthetic method based on glycosyl-1-H-phosphonate diesters has been developed for the preparation of O-d4T-5′-O-glycosyl-1″-phosphoramidate diesters, a kind of potential anti-HIV prodrugs. The target products were synthesized in high yields by using the CCl₄/Et₃N/amino acid methyl ester system.

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Applied Mechanics and Materials (Volume 483)

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79-82

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.483.79

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Online since:

December 2013

Authors:

Shan Shan Gong, Guo Dong Liu, Qing Kun Yang, Qi Sun*

Keywords:

Anti-HIV Prodrug, Antiviral Nucleoside, d4T, H-Phosphonate Diester, Phosphoramidate

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