The Influence of Emulsifiers on the Formation of Res-Loaded Nanostructured Lipid Carriers

Abstract:

Resveratrol has numerous beneficial effects in cosmetic, food and pharmaceutical fields, but the low water solubility keeps it from widely application. In this research, different emulsifier concentrations and emulsifier combinations of Res-loaded NLC were prepared. By studying the mean particle size, polydispersity and zeta potential, in vitro drug release, skin penetration, DPPH scavenging assay and FTIR analysis , the results indicated that the concentration and combination of emulsifier has significant effect on the formation of Res-loaded NLC, and NLC formed with emulsifier combination of PGPR and Tween 60 at 7% concentration is the optimal to stabilize Res-loaded NLC.

• Periodical: Advanced Materials Research (Volume 1118)
• Pages: 118-124
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1118.118
• Online since: July 2015
• Authors: Ting Kang Xing, Rui Sun, Hong Zhang, Qiang Xia*
• Keywords: Emulsifiers, Nanostructured Lipid Carriers, Resveratrol

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