This paper presents the effects of spindle system configuration on the dynamic and static characteristics of high speed grinding. A 3D physical mode of high-speed grinding motorized spindle system with rotation speed of 150m/s was provided. The motorized spindle system consists of bearings, rotor, stator, spindle housing and grinding wheel. Based on the finite element method (FEM), the static characteristics, dynamic and the transient response are analyzed based on the finite element analysis software NASTRAN. It is shown that the spindle overhanging, bearing span have a significant effort on spindle deflection. The dynamic analysis shows no resonance will happen during its speed range. The methods and solutions for the motorized spindle system design and engineering applications was given in this paper.