With catalysis system, carbonylation of methanol liquid is a better method in manufacture of acetic acid. However previous control mode can not well meet technique demands. This paper made some modification on reaction process control based on manufacturing technique. Aimed at much influence upon temperature including uncertainty, cross coupling effects and big delay about model, predictive functional control (PFC) technique combined with PID and feedforward are applied to temperature control of reaction process through supervisory total distributed control which leads to the improvement of regulatory capacity for both reference input tracking and load disturbance rejection. Practical results show stable and reliable system operation.