Preparation of Tetracycline Microparticles Based on Supercritical Fluid Technique

Abstract:

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Inhalation administration requests the microparticles with appropriate average diameters and narrow diameter distribution. In this paper, the tetracycline microparticles suitable for inhalation administration were prepared successfully by Supercritical anti-solvent (SAS) process developed in recent years. A continuous SAS process had been adopted to prepare the micro-particles of tetracycline using ethanol as solvent and supercritical CO2 as anti-solvent. The effects of pressure, temperature, solution concentration and nozzle diameter on the morphology, size and size distribution of the particles were investigated. The results showed that tetracycline micro-particles with diameters range of 20nm to 40nm could be obtained by SAS continuous process when ethanol was used as organic solvent at the experimental operation parameters of the pressure of 15MPa, the temperature of 35°C, the solution concentration of 5mg/ml and the nozzle diameter of 75µm. The nano-particles of tetracycline prepared by the above continuous SAS process can be used for alveolus targeting drug delivery and the preparation of sustained-releases micro-spheres

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

1707-1711

DOI:

10.4028/www.scientific.net/AMR.236-238.1707

Citation:

Y. J. Zhang et al., "Preparation of Tetracycline Microparticles Based on Supercritical Fluid Technique", Advanced Materials Research, Vols. 236-238, pp. 1707-1711, 2011

Online since:

May 2011

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$35.00

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