Synthesis and Potent Biological Activity of 1-Sulfonyl Substituted Imidazole and Benzo[d]imidazole Compounds
A new series of 1-sulfonly substituted imidazole compounds (containing 19 compounds) were synthesized and characterized by 1HNMR, 13CNMR and HRMS. 2d, 2e, 2h, 2i showed promising activities in animal test (in rats) for anti-inflammation. 2k - 2t were used in Chemokine Receptors CXCR4 receptor agonist Calcium assay showed no activities.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Y. J. Ren et al., "Synthesis and Potent Biological Activity of 1-Sulfonyl Substituted Imidazole and Benzo[d]imidazole Compounds", Advanced Materials Research, Vols. 236-238, pp. 2570-2573, 2011