The Anti-Inflammatory Effects of Biomaterials Cross-Linked with Genipin

Yan Fei Song; Shan Shan Ding; Yuan Lu Cui; Qiang Song Wang; Lei Ye; Ye Zhang

doi:10.4028/www.scientific.net/AMR.282-283.412

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 282-283The Anti-Inflammatory Effects of Biomaterials...

The Anti-Inflammatory Effects of Biomaterials Cross-Linked with Genipin

Abstract:

This study was aimed to investigate the anti-inflammatory effects of the chitosan/gelatin membrane cross-linked with genipin (GP). Fourier transform infrared spectrophotometry (FT-IR) was used to characterize the cross-linking reaction. The XTT assay was applied to evaluate the cytotoxicity of the chitosan/gelatin membrane with RAW264.7 cells. Production of nitric oxide (NO) was measured by the Griess colorimetric method. The gene expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and IL-6 were detected by quantitative real-time reverse-transcription polymerase chain reaction (real-time RT-PCR). These results suggested that the anti-inflammatory effects of genipin cross-linked chitosan/gelatin membrane might be the results from modulating the NO/iNOS pathway and inhibiting the mRNA expression of COX-2, IL-6 in activated macrophages.

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Periodical:

Advanced Materials Research (Volumes 282-283)

Pages:

412-416

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.282-283.412

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Online since:

July 2011

Authors:

Yan Fei Song, Shan Shan Ding, Yuan Lu Cui, Qiang Song Wang, Lei Ye, Ye Zhang

Keywords:

Biomaterial, Genipin, Glutaraldehyde, iNOS, RAW 264.7

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