Design and Preparation of 1H-3, 4-Dihydropyrrolo[1,2-a] Pyrazin-1-One via 1H-3,4-Dihydropyrrolo[1,2-C] [1,4] Oxazin-1-One Route

Abstract:

With 2-pyrrolyltrichloroacetone as major starting material, unreported 1H-3,4-dihydropyrrolo- [1,2-a]pyrazin-1-one was prepared successively by its monoesterification with ethylene glycol, bromine displacement of hydroxy group, cyclization to lactone and its amidation. Unreported 7-aroyl-1H-3,4-dihydropyrrolo[1,2-c][1,4]oxazin-1-one compounds were also synthesized in turn by 2-pyrrolyl-trichloroacetone’s Friedel-Crafts acylation and cyclization. Their structures were characterized by IR, 1H NMR, 13C NMR, MS, HRMS, etc.

• Periodical: Advanced Materials Research (Volumes 343-344)
• Pages: 1242-1247
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.343-344.1242
• Online since: September 2011
• Authors: Yong En Guo, Xiao Guang Niu, Cai Ju Zhou, Jie Chu, Wei Wei Xu, Guo Zhen Fang
• Keywords: 1H-3,4-Dihydropyrrolo[1,2-a]Pyrazin-1-one, 7-Aroyl-3,4-Dihydro-1H-Pyrrolo[1, 2-C]-1-one, Friedel-Crafts Acylation, Preparation, Stucture Characterization

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