Preparation and Characterization of Folate-Targeted Chitosan Nanoparticles Loaded with Hydroxycamptothecin

Yi Xiao Wang; Zhen Qing Hou; Fei Cui; Li Hua Shen; Li Ya Xie; Qi Qing Zhang; Yun Feng Yi

doi:10.4028/www.scientific.net/AMR.557-559.434

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 557-559Preparation and Characterization of...

Preparation and Characterization of Folate-Targeted Chitosan Nanoparticles Loaded with Hydroxycamptothecin

Abstract:

FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) were prepared with a combination of emulsion-solvent evaporation and chemical crosslink method. The analysis revealed that the FA-HCPT-NPs were spherical with diameter of 255.5  16.2 nm, zeta potential of + 70 mV, HCPT encapsulation efficiency of 81.2% and loading rate of 2.5%. X-ray powder diffraction illustrated that HCPT was buried as an amorphous form in the NPs. The release profiles of HCPT exhibited a biphasic pattern characterized by an initial burst release followed by a slower and sustained release. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.

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Periodical:

Advanced Materials Research (Volumes 557-559)

Pages:

434-437

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.557-559.434

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Online since:

July 2012

Authors:

Yi Xiao Wang, Zhen Qing Hou, Fei Cui, Li Hua Shen, Li Ya Xie, Qi Qing Zhang, Yun Feng Yi

Keywords:

Chitosan, Folic Acid, Hydroxycamptothecin, Nanoparticle

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