Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test

Abstract:

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Parylene C, an emerging material in microelectromechanical systems (MEMS), is now widely applied to neural prosthesis devices, such as artificial retinal implants, due to its well-known biocompatibility and ability to be easily patterned by oxygen plasma etching. This work presents a flexible parylene-based microelectrode array(MEA)using MEMS techniques aiming for the chronic subretinal stimulation. The MEA was successfully manufactured and inserted into the subretinal space of a rabbit eye by a novel surgical operation. Optical Coherence Tomography(OCT) showed that a chronic implantation of parylene-based electrode arrays in the rabbit retina over a three month follow-up period demonstrated that the present chip system has a good biocompatibility with the subretinal organs without obvious damages.

Info:

Periodical:

Advanced Materials Research (Volumes 60-61)

Edited by:

Xiaohao Wang

Pages:

425-429

DOI:

10.4028/www.scientific.net/AMR.60-61.425

Citation:

X. J. Huang et al., "Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test", Advanced Materials Research, Vols. 60-61, pp. 425-429, 2009

Online since:

January 2009

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Price:

$35.00

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