Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test
Parylene C, an emerging material in microelectromechanical systems (MEMS), is now widely applied to neural prosthesis devices, such as artificial retinal implants, due to its well-known biocompatibility and ability to be easily patterned by oxygen plasma etching. This work presents a flexible parylene-based microelectrode array（MEA）using MEMS techniques aiming for the chronic subretinal stimulation. The MEA was successfully manufactured and inserted into the subretinal space of a rabbit eye by a novel surgical operation. Optical Coherence Tomography(OCT) showed that a chronic implantation of parylene-based electrode arrays in the rabbit retina over a three month follow-up period demonstrated that the present chip system has a good biocompatibility with the subretinal organs without obvious damages.
X. J. Huang et al., "Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test", Advanced Materials Research, Vols. 60-61, pp. 425-429, 2009