Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test

Xian Ju Huang; Wei Hong Yu; Wei Wang; Chan Zhao; Cheng Chen Gao; Xu Qian Wang; Zhi Kun Yang; Zhi Hong Li; Fang Tian Dong

doi:10.4028/www.scientific.net/AMR.60-61.425

Paper Titles

Preparation of Self-Assembly Monolayer by Scratching Si(100) Surface in the Presence of Aryl Diazonium Salts
p.406

Static Torsion of a Magnetostrictive Bimorph with In-Plane Anisotropy
p.410

Carbon Nanofibers Synthesized by Ethanol Catalytic Chemical Vapor Deposition
p.416

Analyzing the Response of Spring-Mass-Capacitor Structure Using Energy Method
p.420

Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test
p.425

Molecular Dynamics Simulation on the Out-of Plane Thermal Conductivity of Single-Crystal Carbon Thin Films
p.430

Molecular Dynamics Modeling and Effects of Cutting Parameters on Nanometric Cutting Process
p.435

Deposition Characteristics of Direct-Write Suspended Micro/Nano-Structures
p.439

Modeling and Simulation of Opposite Type MATA Using MEMS Nodal Cell Library
p.445

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 60-61Flexible Microelectrode Array on Parylene for...

Flexible Microelectrode Array on Parylene for Subretinal Stimulation and its Biocompatibility Test

Abstract:

Parylene C, an emerging material in microelectromechanical systems (MEMS), is now widely applied to neural prosthesis devices, such as artificial retinal implants, due to its well-known biocompatibility and ability to be easily patterned by oxygen plasma etching. This work presents a flexible parylene-based microelectrode array（MEA）using MEMS techniques aiming for the chronic subretinal stimulation. The MEA was successfully manufactured and inserted into the subretinal space of a rabbit eye by a novel surgical operation. Optical Coherence Tomography(OCT) showed that a chronic implantation of parylene-based electrode arrays in the rabbit retina over a three month follow-up period demonstrated that the present chip system has a good biocompatibility with the subretinal organs without obvious damages.