Advanced Materials Research Vols. 634-638

Abstract: In the paper, N,N′-bis(4-hydroxybenzyidene)azine (BHBYA) has been synthesized by p-hydroxybenzaldehyde and hydrazine as raw materials. The structure was determined by X-ray diffraction. The Schiff base crystallizes is in the monoclinic P21/c space group. The results of antimicrobial activity showed that it has a good inhibition on Cucumber Damping-Off and Rice Blast. The findings of oxidation resistance experiment indicated that it has an excellent inhibitory effect on peroxidation of olein.

Abstract: Sixteen 3-arylurea-5-fluoroindolin-2-one derivatives were designed according to the principle of fragment based drug discovery and synthesized with 5-fluoroisatin as the starting material. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, activities of 6a, 6h, and 6j in tumor inhibition were better than others.

Abstract: Nine 5-fluoroindolin-2-one derivatives with urea linkage were designed and synthesized. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, compounds 6e and 6f, which were better than or equal to the antitumor activity of positive control.

Abstract: BRAF, a serine/threonine specific protein kinase that is part of the MAPK pathway and acts as a downstream effector of RAS, is a potential therapeutic target in melanoma. We have studied a series of small-molecule BRAF inhibitors based on a 1H-imidazo[4,5-b]pyridine-2(3H)-one scaffold (ring A) as the hinge binding moiety and a number of substituted phenyl rings C that interact with the allosteric binding site. Based on molecular docking obtained by using GOLD, the interaction models on the receptor site of BRAF are guiding the design of potential inhibitory structures directed against BRAF activity.

Abstract: Reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR) was used to determine the differential expression of the Dmrt1 gene in ovaries of diploid and triploid rainbow trout (Oncorhynchus mykiss) 10 and 20 months post-hatch. At 10 months post-hatch there was little relative difference in the expression of the Dmrt1 gene between triploid and diploid trout. However, at 20 months the expression of the Dmrt1 gene in triploids was more than 14 times higher than in diploids. Dmrt1 expression from 10 to 20 months suggests masculinization of the ovaries, which may be virilescent in triploid females at the later development phase (20 months). This study provides molecular evidence supporting the general claims that ovaries of female triploid rainbow trout do not develop normally resulting in sterility.

Abstract: The impact of HPD722 macroporous resin on the dynamic adsorption and desorption of flavonoids in Emilia Sonchifolia extract is studied. The diameter-height ratio of macroporous resin column is 1:10; the mass concentration of the sample solution is selected to be 50.00 mg•mL-1; while the sample flow rate is 3.00mL min-1; upon dynamic absorption for once, the absorption rate reaches 81.11%; with adoption of 50mL ethanol at a volume ratio of 60% as the desorption agent, the desorption flow rate comes to 3.00mL•min-1; and the desorption rate of flavonoids attains 85.26%. Under optimal conditions, the content of flavonoids increases from 6.05% to 32.65% upon purification by HPD722 macroporous resin.

Abstract: Formula for microcellular unsaturated polyester using chemical foaming method was studied. With the increase of NaHCO3 content, the cell size of microcellular unsaturated polyester slightly decreased with the increase of styrene content in the range of 1-2 %. The cell size increased in the range of 2-4 %. With the increase of curing agent content, the cell size increased in the range of 0.5-0.9 % and decreased in the range of 0.9-1.3 %. The cell size decreased with the increase of styrene content in the range of 30-40 %. The cell size had little variation when styrene content was in the range of 40-50 %. The average cell size and cell density of microcellular unsaturated polyester were strongly affected by accelerant content. The cell size decreased with the increase of accelerant content. The opposite was for the cell density. The microcellular unsaturated polyester prepared at 2% NaHCO3, 0.3% accelerantt, 0.9% curing agent, 40% styrene had the small cell size, high cell density, and strong compression strength.

Abstract: Flame retardance and thermal degradation of CMC-Na fibers were investigated using limiting oxygen index (LOI), thermal gravimetry (TG), differential TG (DTG) and Scanning electron microscopy (SEM). The LOI values of different CMC-Na fibers are 23, 26, 28.5, 31 and 34, compared with about 20 for viscose fiber. TG and DTG studies indicate that the temperature of maximum degradation rate and the maximum degradation rate for CMC-Na fibers are much lower than those of viscose fiber. However, CMC-Na fibers generate much more residues or carbonaceous char than does viscose fiber. The increase of sodium ion content, the carbon residual also increases. SEM studies of combustion residues after LOI testing indicate that all CMC-Na fibers produce intumescent, hard and brittle residue crusts.

Abstract: Self-cleaning fabrics have been successfully prepared by depositing and grafting TiO₂ nanoparticles, and silane coupling agent 3-Aminopropyltriethoxysilane was adopted to improve the photocatalytic activity of self-cleaning fabrics. TEM results showed that the treatment of silane coupling agent is good for increasing the amount of TiO₂ particles. The excellent photocatalytic activity of TiO₂-coated cotton fabrics is attributed the increase of TiO₂ particles and the formation of the TiO₂/SiO₂ structure.

Abstract: In this research, xylan was utilized by a recombinant whole cell biocatalyst, which was developed by expressing three xylanases — β-xylosidase, endoxylanase, and α-arabinofuranosidase — on the surface of the E. coli BL21 (DE3). The xylanases were displayed on the surface of the cells by fusing with anchor proteins, Blc. The assimilation of xylan by cell surface display was the first step in the consolidated bioprocessing (CBP). This result shows that the engineering strains could be endowed with the ability to assimilate xylan. The co-display engineering strains utilized xylan and expressed less metabolic burden than the engineering strains secreting extracellular xylanases.