Resveratrol Inhibition Osteoclastogenesis Induced by RANKL through Decrease Preosteoclast Formation

Shang Chien Lin; Sheng Yu Kao; Nien Tzu Keng; Wei Chung Liu

doi:10.4028/www.scientific.net/AMR.647.124

Paper Titles

Investigation on Osteoblast Growth on the Modified Surface of Porous Titanium
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Study on Cellar Behaviors on Different Micro/Nano Structures of Anodic Aluminum Oxide Template
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Chitosan Induced Synthesis of EuPO₄ Nanoparticles on Fiber Templates for Live Imaging
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Resveratrol Inhibition Osteoclastogenesis Induced by RANKL through Decrease Preosteoclast Formation
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Codepositon of Dopamine/Calcium on Titanium to Enhancing Implant Integration
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Preparation and Characterization of Alveolar Bone and Periodontal Ligament Interface Scaffolds
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Experimental Study of the Biochemistry Method for Enhancing Oil Recovery in the Oil Reservoir after Polymer Flooding
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 647Resveratrol Inhibition Osteoclastogenesis Induced...

Resveratrol Inhibition Osteoclastogenesis Induced by RANKL through Decrease Preosteoclast Formation

Abstract:

It has been demonstrated that resveratrol can inhibit osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand (RANKL) in several cell models. However, the mechanism has not yet been completely clarified. In this study, we investigated the effects of resveratrol on osteoclasts differentiation induced by RANKL. Preosteoclast or osteoclast derived from the murine monocytic cell line RAW264.7 treated with RANKL. In RAW264.7 cells culture, data indicated that resveratrol at non-toxic concentrations dose-dependently inhibited the formation of osteoclasts and the activation of tartrate-resistant acid phosphatase (TRAP). Using flow cytometry assay, the results indicated that the percentage of preosteoclast differentiation was decreased by resveratrol, whereas the apoptosis rate of preosteoclasts was not changed. Our results suggest that resveratrol might inhibit the differentiation of RAW264.7 cells into osteoclasts and decrease osteoclast activation possibly via suppressing monocytes to differentiate preosteoclasts.

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Periodical:

Advanced Materials Research (Volume 647)

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124-128

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https://doi.org/10.4028/www.scientific.net/AMR.647.124

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January 2013

Authors:

Shang Chien Lin, Sheng Yu Kao, Nien Tzu Keng, Wei Chung Liu

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Osteoclast, Osteoclastogenesis, Resveratrol

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