Preparation and Characterization of Alveolar Bone and Periodontal Ligament Interface Scaffolds

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Abstract:

To mimic the alveolar bone and periodontal ligament interface, a chitosan(CS for short) composite polysaccharide scaffold was fabricated which was cross-linked with sodium alginate(SA for short). The conditions of physical crosslinking in the scaffolds were discussed. By characterization after biomineralization, it turns out that pH=5.0 and 40min crosslinking time can make for crosslinking. Better crosslinking makes the material more antiswelling and give more compressive strength. In the other hand, the biomineralization can improve the physical properties of the material. We hope that after further research it can come to a scaffold material with good properties.

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133-138

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January 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] Popowics T, Yeh K, Rafferty K, Herring S. Functional cues in the development of osseous tooth support in the pig, Sus scrofa. J Biomech 2009; 42(12): 1961-6.

DOI: 10.1016/j.jbiomech.2009.05.016

Google Scholar

[2] Reichenberger E, Baur S, SuKotjo C, Olesen BR, Karimbux NY, Nishimura I. Collagen Xll mutation disrupts matrix structure of periodontal ligament and sKin. J Dent Res 2000; 79(12): 1962-8.

DOI: 10.1177/00220345000790120701

Google Scholar

[3] Moffat KL, Sun WH, Pena PE, Chahine NO, Doty SB, Ateshian GA, et al. Characterization of the structure-function relationship at the ligament-to-bone inerface. Proc Natl Acad Sci U.S. A 2008; 105(23): 7947-52.

DOI: 10.1073/pnas.0712150105

Google Scholar

[4] Chan Ho ParK, Hector F. Rios, Qinging Jin, Megan E. Bland, Colleen L. Flanagan, Scott H. Hollister, William V. Giannobile. Biomometic hybrid scaffolds for engineering human tooth-ligament interfaces. Biomaterials 2010; 31(23): 5945-52.

DOI: 10.1016/j.biomaterials.2010.04.027

Google Scholar

[5] Schnüriger B, Barmparas G, Branco BC, Lustenberger T, Inaba K, Demetriades D. The American Journal of Surgery. 2011; 201: 111-21.

DOI: 10.1016/j.amjsurg.2010.02.008

Google Scholar

[6] Yalpani M., Hall L. D., Macromolecules [J], 1984, 17(3): 272—281.

Google Scholar