Preparation and Characterization of PMMA-Based Cements Containing Magnetic Nanoparticles for the Magnetic Hyperthermia

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Three types of polymethylmethacrylate(PMMA)-based cements containing magnetic (Fe3O4) particles were developed and their properties were evaluated. The commercial available PMMA cement (PMMAc) was used as a control material. The setting time of the cement extended while the compressive strength of the samples decreased with increasing Fe3O4 content. There was no obvious difference in peak temperature between the cements during the setting reaction. The cement with 10 wt% Fe3O4 in an alternating magnetic field (AMF) of 125 Gs and cement with 20 wt% Fe3O4 in an AMF of 100 Gs could generate enough heat for the therapeutic hyperthermia of bone metastasis.

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155-159

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January 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] Uchida A, Wakabayashi H, Okuyama N, Okamura A, Matsumine A, Kusuzaki K, Metastatic bone disease: pathogenesis and new strategies for treatment, J Orthop Sci. 9(2004)415-420.

DOI: 10.1007/s00776-004-0788-1

Google Scholar

[2] Akhtari M, Mensuri J, Newman KA, Guise TM, Seth P, Biology of breast cancer bone metastasis, Cancer Biol Ther. 7(2008)3-9.

Google Scholar

[3] Aaron AD, Treatment of metastatic adenocarcinoma of the pelvis and the extremities, J Bone Joint Surg. 79(1997)917-932.

Google Scholar

[4] Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, et al, A novel hyperthermia treatment for bone metastases using magnetic materials, Int J Clin Oncol. 16(2011)101-108.

DOI: 10.1007/s10147-011-0217-3

Google Scholar

[5] Drosos GI, Babourda E, Magnissalis EA, Giatromanolaki A, Kazakos K, Verettas DA, Mechanical characterization of bone graft substitute ceramic cements, Injury. 43(2012)266-271.

DOI: 10.1016/j.injury.2011.02.004

Google Scholar

[6] Kenny. SM, Buggy, M, Bone cements and fillers: A review, Journal of Materials Science-Materials in Medicine. (11)2003: 923-938.

Google Scholar

[7] Chang ST, Hong YC, Kwo PC, Using chemical coprecipitation method to prepare magnetite magnetic fluids and explore its applications in hyperthermia, Key Engineering Materials. 2011; 474-476: 1776-1780.

DOI: 10.4028/www.scientific.net/kem.474-476.1776

Google Scholar

[8] Kawashita M, Kawamura K, Li Z, PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer, Acta Biomaterialia. 6(2011)3187-3192.

DOI: 10.1016/j.actbio.2010.02.047

Google Scholar

[9] Breusch, SJ, Cementing technique in total hip replacement: Factors influencing survival of femoral components, bone cements and cementing technique. (2001)53-79.

DOI: 10.1007/978-3-642-59478-6_6

Google Scholar

[10] van der Zee J, Heating the patient: a promising approach?, Ann Oncol. 13(2002): 1173-1184.

Google Scholar