Synthesis and Characterization of Cholesterol-(1,2,3-triazole)-PEG via Click Chemistry

Wan Xu; Bing Hong Luo; Cai Rong Li; Jing Yang; Chang Ren Zhou

doi:10.4028/www.scientific.net/AMR.647.499

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 647Synthesis and Characterization of...

Synthesis and Characterization of Cholesterol-(1,2,3-triazole)-PEG via Click Chemistry

Abstract:

Firstly, toluenesulfonyl cholesterol was synthesized by the reaction of cholesterol and p-toluenesulfonyl chloride, and then reacted with sodium azide to obtain azido-cholesterol. Secondly, propargyl was introduced into the terminal groups of polyethylene glycol (PEG) by the reaction of PEG and bromine propargyl. Lastly, cholesterol-(1,2,3-triazole)-PEG oligomer was prepared by the reaction of the azido-cholesterol and propargyl-PEG via click chemistry using CuSO4.5H2O as a catalyst. The structures of the products were characterized by the FTIR and 1H NMR analysis.

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Periodical:

Advanced Materials Research (Volume 647)

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499-503

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https://doi.org/10.4028/www.scientific.net/AMR.647.499

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Online since:

January 2013

Authors:

Wan Xu, Bing Hong Luo, Cai Rong Li, Jing Yang, Chang Ren Zhou

Keywords:

Cholesterol, Click Chemistry, Polyethylene Glycol (PEG), Synthesis

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