Fabrication of Asymmetric Polysaccharide Composite Membranes for Prevention of Post-Surgical Peritoneal Adhesion

Abstract:

The prevention of undesired abdominal wall adhesion after surgery was investigated using asymmetric polysaccharide composite membranes as physical barriers. The hyaluronate (HA) and chitosan (CS) based asymmetric composite membranes were prepared with one smooth surface to inhibit fibroblasts and one porous surface to improve the tissue cells. With adaption of the reaction temperature, pH and component ratios, a series crosslinked membranes were processed with different appearance, mechanical strength and swelling ratios. Cell culture results showed the fibroblasts were inhibited on the composite membranes with comparison of that on petri dish. The osteoblasts proliferated obviously on the porous surface. The composite membranes resulted in less post-operative adhesion of the peritoneum and cecum than shown by non-treated rats without physical barriers, which could be used as a physical barrier to prevent abdominal post-operative adhesion during healing.

• Periodical: Advanced Materials Research (Volume 647)
• Pages: 518-523
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.647.518
• Online since: January 2013
• Authors: Bi Hua Ye, Jia Hao Su, Guo Dong Sun, Li Hua Li, Jie Chen, Chen Zhou, Chang Ren Zhou
• Keywords: Asymmetric Membrane, Chitosan, Hyluronate, Prevention of Adhesion

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