In Vivo Osteogenic Effect of Porous β- CaSiO₃/PDLGA Composite Scaffolds

Abstract:

The aim of the present study is to evaluate the in vivo biological behaviour of porous β-CS/PDLGA scaffolds. The scaffolds were implanted in critical-sized femur defects ( 6 ×10 mm) for 4, 12 and 20 weeks with β-TCP scaffolds as the control. The in vivo bone regeneration of the scaffolds were investigated using sequential histological evaluations and Micro-CT technology. Results showed that the β-CS/PDLGA scaffolds could stimulate bone regeneration and degrade progressively at a rate proportionate with the regeneration of new bone as compared with β-TCP scaffolds. The present study suggested the potential application of β-CS/PDLGA scaffolds in hard tissue regeneration.

• Periodical: Advanced Materials Research (Volume 647)
• Pages: 94-97
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.647.94
• Online since: January 2013
• Authors: Chen Wang, Kai Li Lin, Jiang Chang, Jiao Sun
• Keywords: Osteogenesis, Rabbit, rBMSCs, β-CS/PDLGA

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