Biological Performances Investigation of KGM/SH Fiber Membranes

Abstract:

Fiber woven membranes were prepared with konjac glucomannan (KGM) and sodium hyaluronate (SH). Glycerol was added as plasticizer and lactic acid as modifier. After treatment with microwave,wet spinning method and the programmable 2D mobile platform were used to prepare the KGM/SH fiber woven membranes. The in vitro degradability of the fiber membranes was tested by PBS immersion. The biological activity of the fiber woven membranes was observed by SBF mineralization experiments. The cytocompatibility was also investigated via co-culture of stem cells. It was revealed that the fiber woven membranes had good biological activity, degradation rate and cytocompatibility, which indicated that the membrane has a good prospect as a potential cartilage scaffold.

• Periodical: Advanced Materials Research (Volume 738)
• Pages: 61-66
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.738.61
• Online since: August 2013
• Authors: Yin Li, Xiao Pei Wu, Yong Shun Cui, Chong Yan Leng, Ting Ting Yan, Qing Hua Chen
• Keywords: Cartilage Scaffold, Fiber Membranes, Konjac Glucomannan, Sodium Hyaluronate

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