Effect of Konjac Glucomannan Content on the Structure and Properties of Sodium Hyaluronate/Chitosan/Konjac Glucomannan Composite Films

Abstract:

Unsoluble composite films have been prepared by blending konjac glucomannan (KGM)/sodium hyaluronate (SH) aqueous solution with chitosan (CS) solution in acetate solution, filtering, deaerating, tape casting, drying at 55°C for 8h and crosslinking with the aid of sodium hydroxide solution for 2h. The effect of KGM content on the structure and properties of SH/CS/KGM composite films were investigated. It was indicated that the KGM can significantly improve the tensile strength (σ_b) and breaking elongation (ε_b) of the SH/CS composite films, and the tensile strength (σ_b) and breaking elongation (ε_b) increased with the increase of KGM content in composite films. It was revealed by IR and X-ray analysis that the crystallinity of composite films decreased with the increase of KGM content and the composite films was mainly amorphous. It was indicated via scanning electron microscopy (SEM) and bone marrow mesenchymal stem cell experiments that the films could support the growth of cells and were non-toxicity and good biocompatibility.

• Periodical: Advanced Materials Research (Volume 738)
• Pages: 67-72
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.738.67
• Online since: August 2013
• Authors: Wei Bo Zhu, Jia Chen, Tin Ting Yan, Wei Bo Zhu, Qing Hua Chen
• Keywords: Biocompatibility, Chitosan, Composite Film, Konjac Glucomannan, Mechanical Property, Sodium Hyaluronate

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