Preparation and Characterization of Guanidinylated Chitosan/β-Glycerophosphate Thermo-Sensitive Hydrogel

Xue Jie Qi; Yuan Lu Cui; Qiang Song Wang; Yun Qi

doi:10.4028/www.scientific.net/AMR.749.182

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 749Preparation and Characterization of Guanidinylated...

Preparation and Characterization of Guanidinylated Chitosan/β-Glycerophosphate Thermo-Sensitive Hydrogel

Abstract:

The purpose of this study was to prepare and characterize guanidinylated chitosan/β-glycerophosphate thermo-sensitive hydrogel system. The primary amine group of chitosan was modified with guanidine group, which was characterized by FT-IR and ¹H NMR. The results showed that the guanidinylations had been successfully carried out in cyanamide and chitosan. Gelation temperature was modulated at 37 °C with the ratio of 50% β-GP solution (weight/volume) and 4% GCS solution (weight/volume) at pH value ranged from 6.9 to 7.2, which could be development a new drug delivery system at body temperature.

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Periodical:

Advanced Materials Research (Volume 749)

Pages:

182-185

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.749.182

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Online since:

August 2013

Authors:

Xue Jie Qi, Yuan Lu Cui, Qiang Song Wang, Yun Qi

Keywords:

Guanidinylated Chitosan (GCS), Hydrogel, β-Glycerophosphate (β-GP)

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