Schisandrae chinensis Extract Repaired Microwave Induced Hepatic Injury

Yan Li; Yv Lian Liu; Wei Zhang; Peng Yan Ji; Dong Hai Zhao; Qing Hua Li; Shi Jie Lv

doi:10.4028/www.scientific.net/AMR.915-916.954

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Schisandrae chinensis Extract Repaired Microwave Induced Hepatic Injury

Abstract:

To investigate the influence of Schisandrae Chinensis Extract on hepatic injury of rats with microwave. Wistar rats were randomly divided into three groups (control group, microwave radiation group and schisandrae chinensis extract prevention group). Then the rats of schisandrae chinensis extract prevention group were supplyed individually with schisandrae chinensis extract for 5 days before the microwave radiation. After that, the morphology of the livers was observed using HE staining, and the expressions of t-JNK1/2 and p-JNK1/2 were analyzed by western-blotting in the rats. The histological results showed the pathological injury in the liver tissue was improved in all schisandrae chinensis extract prevention groups, and a significant increase of p-JNK1/2 was observed in liver cells after treatment with 200mW/cm² microwave for 24 h. It also show that pretreated with schisandrae chinensis extract could inhibit the phosphorylation of JNK1/2. These results suggested that schisandrae chinensis extract could obviously lessened the hepatic injury induced by microwave.