Protein Adsorption on Titanium Surface Functionalized with Bioactive Gelatin Methacrylate Hydrogel Coating

Guo Xin Tan; Ying Tan; Cheng Yun Ning; Lin Zhang; Lei Zhou; Hang Wang

doi:10.4028/www.scientific.net/AMR.936.663

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 936Protein Adsorption on Titanium Surface...

Protein Adsorption on Titanium Surface Functionalized with Bioactive Gelatin Methacrylate Hydrogel Coating

Abstract:

Gelatin methacrylate (GelMA) hydrogel comprised of modified natural extracellular matrix (ECM) components, making it a potentially attractive material for surface modification. In this paper, we hypothesize that establishing a GelMA hydrogel coating on titanium surface will accelerate osseointegration. Titanium substrates were silanized with 3-Aminopropyltriethoxysilane (APTES), which was treated by alkali-heated treatment firstly. The GelMA hydrogel coating was constructed on the silanized titanium surface by in situ photopolymerization under UV illumination. Adsorption of bovine serum albumin (BSA) onto modifed titanium surfaces was investigated. The results showed that GelMA-coated titanium adsorbed greater amount of protein than other Ti surfaces. The differences in protein adsorption behavior could result in very different initial cellular behavior on GelMA-coated titanium implant surfaces.

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Advanced Materials Research (Volume 936)

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663-668

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https://doi.org/10.4028/www.scientific.net/AMR.936.663

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June 2014

Authors:

Guo Xin Tan*, Ying Tan, Cheng Yun Ning, Lin Zhang, Lei Zhou, Hang Wang

Keywords:

Gelatin Methacrylate Hydrogel, Protein Adsorption, Titanium Surface Modification

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