Study of Multi-b-Value Diffusion-Weighted Imaging at 3.0 T for Measuring Renal Function of Patients with Chronic Renal Failure

Abstract:

To investigate the relationship between apparent diffusion coefficient (ADC) values measured by diffusion-weighted imaging (DWI) on a 3.0T MR unit and glomerular filtration rate (GFR) determined by renal imaging using Nuclear Medicine ⁹⁹ Tcm-DTPA. 3.0T MRI DWI and 99 Tcm-DTPA renal imaging were simultaneously performed in 30 patients with chronic renal failure. The b values set for DWI imaging were 0, 200, 400, 600, 800 and 1000 s/mm2 and the ADC values of renal cortex were measured. 60 kidneys from the patients were classified into three groups according to the measurements of GFR: mildly impaired renal function, moderately impaired renal function and severely impaired renal function. ADC values of the three groups were compared to determine whether there existed statistic difference and the correlation between ADC values and GFR was also measured. Statistical difference was found in ADC values of the three groups and a positive correlation was identified between ADC values and GFR (r = 0.623). Multi-b-value diffusion-weighted MR imaging at 3.0 T can be used to assess renal filtration function.Abbreviation used: DWI, diffusion-weighted imaging; ADC, apparent diffusion coefficient; GFR, glomerular filtration rate; NEX, number of excitation.

• Periodical: Advanced Materials Research (Volumes 998-999)
• Pages: 320-324
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.998-999.320
• Online since: July 2014
• Authors: Jun Lai Xue, Meng Chao Zhang, Mao Hua Zhang, Dong Tong, Wu Qiang*
• Keywords: B Value, Diffusion-Weighted Imaging, Glomerular Filtration Rate, Magnetic Resonance Imaging (MRI)

References

[1] Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. M E Moseley, Y Cohen, J Kucharczyk, J Mintorovitch, H S Asgari, M F Wendland, J Tsuruda, and D Norman Radiology 1990 176: 2, 439-445.

DOI: 10.1148/radiology.176.2.2367658

[2] Beaulieu, C. (2002), The basis of anisotropic water diffusion in the nervous system – a technical review. NMR Biomed., 15: 435–455. doi: 10. 1002/nbm. 782.

DOI: 10.1002/nbm.782

[3] Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis, Osamu Abe, Shigeki Aoki, Naoto Hayashi, Haruyasu Yamada, Akira Kunimatsu, Harushi Mori, Takeharu Yoshikawa, Toshiyuki Okubo, Kuni Ohtomo, Neurobiology of Aging - May 2002 (Vol. 23, Issue 3, Pages 433-441).

DOI: 10.1016/s0197-4580(01)00318-9

[4] Brain R.F. Barajas, Jr, J.L. Rubenstein, J.S. Chang, J. Hwang, and S. Cha, Diffusion-Weighted MR Imaging Derived Apparent Diffusion Coefficient Is Predictive of Clinical Outcome in Primary Central Nervous System Lymphoma, AJNR Am J Neuroradiol 2010 31: 60-66originally published online on September 3, 2009, 10. 3174/ajnr. A1750.

DOI: 10.3174/ajnr.a1750

[5] Koh, D. M., & Collins, D. J. (2007). Diffusion-weighted MRI in the body: applications and challenges in oncology. American Journal of Roentgenology, 188(6), 1622-1635.

DOI: 10.2214/ajr.06.1403

[6] Kwee, T. C., Takahara, T., Ochiai, R., Nievelstein, R. A., & Luijten, P. R. (2008).

[7] Chandarana, H., Lee, V. S., Hecht, E., Taouli, B., & Sigmund, E. E. (2011).

[8] Taouli, Bachir, Ravi K. Thakur, Lorenzo Mannelli, James S. Babb, Sooah Kim, Elizabeth M. Hecht, Vivian S. Lee, and Gary M. Israel. Renal Lesions: Characterization with Diffusion-weighted Imaging versus Contrast-enhanced MR Imaging 1., Radiology 251, no. 2 (2009).

DOI: 10.1148/radiol.2512080880

[9] Cova, M., Squillaci, E., Stacul, F., Manenti, G., Gava, S., Simonetti, G., & Pozzi-Mucelli, R. (2014). Diffusion-weighted MRI in the evaluation of renal lesions: preliminary results.

DOI: 10.1259/bjr/26525081

[10] Fukuda Y, Ohashi I, Hanafusa K, et al. Anisotropic diffusion in kidney: apparent diffusion coefficient measurement s for clinical use [ J] . J Magn Reson Imaging, 2000, 11( 2) : 156-160.

DOI: 10.1002/(sici)1522-2586(200002)11:2<156::aid-jmri12>3.0.co;2-8

[11] Ries, M., Jones, R. A., Basseau, F., Moonen, C. T., & Grenier, N. (2001). Diffusion tensor MRI of the human kidney. Journal of Magnetic Resonance Imaging, 14(1), 42-49.

DOI: 10.1002/jmri.1149

[12] Chow, L. C., Bammer, R., Moseley, M. E., & Sommer, F. G. (2003). Single breath‐hold diffusion‐weighted imaging of the abdomen. Journal of Magnetic Resonance Imaging, 18(3), 377-382.

DOI: 10.1002/jmri.10353

[13] Jones RA, Grattan-Smith JD. Age dependence of the renal apparent diffusion coef –ficient in children [ J ] . Pediatr Radiol, 2003, 33 (12) : 850-854.

DOI: 10.1007/s00247-003-0982-x

[14] Xu Y, Wang X, J iang X. Relationship between the renal apparentdiffusion coefficient and glomerular filtration rate: preliminary experience[ J ]. J Magn Reson Imaging, 2007, 26 (3) : 6782681.

DOI: 10.1002/jmri.20979

[15] Thoeny HC, De Keyzer F, Oyen RH, et al. Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchyma diseases: initial experience. Radiology. 2005, 235: 911.

DOI: 10.1148/radiol.2353040554

[16] Toyoshima S, Noguchi K, Seto H, et al. Functional evaluation of hydronephrosis by diffusion-weighted MR imaging. Relationship between apparent diffusion coefficient and split glomerular filtration rate. Acta Radiol, 2000, 4 1: 642.

DOI: 10.1080/028418500127346063