Bioactive Constituents and Potency of Aqueous-Methanolic Extract of Asclepias syriaca on Plasmodium falciparum Infected Albino Rats

Abstract:

High mortality rate couple with the economic effect of deadly Plasmodium falciparum caused by malaria necessitated this study. Evaluation of bioactive constituents and antimalarial properties of the aqueous-methanolic extract of Asclepias syriaca (A. syriaca) was investigated. Bioactive constituents were determined by GC-MS analytical detector. Albino rats were five in each group of six groups (A-E) in which group A was non-infected with P. falciparum (negative control). Groups B, C, D, E were infected with 1×10⁷/ml P. falciparum without treated, treated with standard drugs of 20mg of chloroquine/kg, 100, 200 and 400mg of extracted A. syriaca/kg, respectively. Hematological and biochemical parameters of Plasmodium falciparum infected albino rats were determined. Aqueous-methanolic extract of A. syriaca leaf made up of high content of pyrimidine, quinolone and silane derivatives with synergetic properties with potency for therapeutic of malarial and viral infectious diseases. MCV, PLA, RBC, total protein and albumin were significantly elevated upon infected P. falciparum and gradually increases with dosage and time when treated with chloroquine and A.syriaca leaf extract but vice visa for the case WBC and creatinine. Parasitemia level significantly declined when administered with chloroquine and A, syriaca leaf extract for 36 hours. Hence serves as an effective medication in place of chloroquine due to its availability, avoidable and as a source of relevant medications to Plasmodium spp and viral infectious diseases.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 51)
• Pages: 15-28
• DOI: https://doi.org/10.4028/www.scientific.net/JBBBE.51.15
• Online since: June 2021
• Authors: Oladimeji Taofik Azeez*, Iwuji Samuel Chidi, Samuel Chidi Uzoechi, Ejeta Kennedy Oghenenyore, Ajuogu Eno, Emmanuel Tochukwu Chibuike, Okafor Loretta Afoma
• Keywords: Asclepias syriaca, Bioactive Constituents, Hematology, Plasmodium falciparum

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