Fabrication and Characterization of Alginate Hydrogels for Control Release System of Catechin-Derived Tea Leave Extract

Abstract:

Polyphenolic chemicals found in tea leaves are frequently used in pharmaceutics and the food industry. Catechin is a polyphenol that has antimicrobial, antioxidant, and antibacterial effects, as well as other health advantages. The goal of this study was to create a catechin-encapsulated alginate hydrogel (Cate-ALG) that would protect catechin from degradation and bioactivity loss in stressful environments while also delivering catechin. The antioxidant ability of catechin was found to be greater than that of vitamin C using the 2,2-diphenyl-1-pierylhyrazyl assay. The FT-IR spectra revealed the distinct peaks of catechin and alginate. Additionally, due to the hydrogen bond interaction between alginate and catechin molecules, frequency downshifting was observed in the carbonyl and hydroxyl regions. Furthermore, release profile revealed a burst release of 5% catechin-ALG in the first 25 min. On the other hand, the 3% Cate-ALG approached the controlled release profile of catechin and increased the release time by more than 40 minutes. The catechin in alginate hydrogel has the potential for controlled release via transdermal and wound dressing applications.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 58)
• Pages: 97-107
• DOI: https://doi.org/10.4028/p-63176q
• Online since: August 2022
• Authors: Vu Viet Linh Nguyen, Gia Quynh Nhu Pham, Thi Hong Anh Nguyen, Van Cuong Nguyen*
• Keywords: Alginate Hydrogel, Antioxidants, Catechin, Controlled Release

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